Origins and antiquity of x-linked triallelic color vision systems in new world monkeys

Stephane Boissinot, Ying Tan, Song Kun Shyue, Horacio Schneider, Iracilda Sampaio, Katherine Neiswanger, David Hewett-Emmett, Wen Hsiung Li

Research output: Contribution to journalArticle

Abstract

It is known that the squirrel monkey, marmoset, and other related New World (NW) monkeys possess three high-frequency alleles at the single X- linked photopigment locus, and that the spectral sensitivity peaks of these alleles are within those delimited by the human red and green pigment genes. The three alleles in the squirrel monkey and marmoset have been sequenced previously. In this study, the three alleles were found and sequenced in the saki monkey, capuchin, and tamarin. Although the capuchin and tamarin belong to the same family as the squirrel monkey and marmoset, the saki monkey belongs to a different family and is one of the species that is most divergent from the squirrel monkey and marmoset, suggesting the presence of the triallelic system in many NW monkeys. The nucleotide sequences of these alleles from the five species studied indicate that gene conversion occurs frequently and has partially or completely homogenized intronic and exonic regions of the alleles in each species, making it appear that a triallelic system arose independently in each of the five species studied. Nevertheless, a detailed analysis suggests that the triallelic system arose only once in the NW monkey lineage, from a middle wavelength (green) opsin gene, and that the amino acid differences at functionally critical sites among alleles have been maintained by natural selection in NW monkeys for >20 million years. Moreover, the two X-linked opsin genes of howler monkeys (a NW monkey genus) were evidently derived from the incorporation of a middle (green) and a long wavelength (red) allele into one chromosome; these two genes together with the (autosomal) blue opsin gene would immediately enable even a male monkey to have trichromatic vision.

Original languageEnglish (US)
Pages (from-to)13749-13754
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number23
DOIs
StatePublished - Nov 10 1998

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Platyrrhini
Color Vision
Alleles
Callithrix
Saimiri
Genes
Haplorhini
Alouatta
Cebus
Opsins
Gene Conversion
X-Linked Genes
Genetic Selection
Gene Frequency
Chromosomes
Amino Acids

ASJC Scopus subject areas

  • General

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Origins and antiquity of x-linked triallelic color vision systems in new world monkeys. / Boissinot, Stephane; Tan, Ying; Shyue, Song Kun; Schneider, Horacio; Sampaio, Iracilda; Neiswanger, Katherine; Hewett-Emmett, David; Li, Wen Hsiung.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 23, 10.11.1998, p. 13749-13754.

Research output: Contribution to journalArticle

Boissinot, Stephane ; Tan, Ying ; Shyue, Song Kun ; Schneider, Horacio ; Sampaio, Iracilda ; Neiswanger, Katherine ; Hewett-Emmett, David ; Li, Wen Hsiung. / Origins and antiquity of x-linked triallelic color vision systems in new world monkeys. In: Proceedings of the National Academy of Sciences of the United States of America. 1998 ; Vol. 95, No. 23. pp. 13749-13754.
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