Ordering of six polymorphic DNA markers important in the delineation of 3p deletions in neoplasia

A. C. Heppell-Parton, D. G. Albertson, Donna Albertson

Research output: Contribution to journalArticle

Abstract

Using fluorescence in situ hybridisation (FISH) the chromosomal location and relative order of six human chromosome 3 probes has been determined. The sensitivity of the technique has enabled the relative mapping of probes carrying inserts as small as 500 basepairs (bp), thus allowing the following proximal-distal probe order to be proposed: D3S30 (3p13-14), D3S4 (3p13-14), D3S2 (distal 3p14), D3S32 (3p21), D3S48E (3p21-23), and D3S11 (3p22-23). These data combined with the deletion mapping data of other researchers raise the possibility that the loss of more than one region of the short arm of chromosome 3 may be important in the development of small cell lung cancer.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalGenes Chromosomes and Cancer
Volume4
Issue number3
DOIs
StatePublished - 1992

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Chromosomes, Human, Pair 3
Genetic Markers
Small Cell Lung Carcinoma
Human Chromosomes
Fluorescence In Situ Hybridization
Neoplasms
Research Personnel
Monosomy 3p Chromosome 3

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Ordering of six polymorphic DNA markers important in the delineation of 3p deletions in neoplasia. / Heppell-Parton, A. C.; Albertson, D. G.; Albertson, Donna.

In: Genes Chromosomes and Cancer, Vol. 4, No. 3, 1992, p. 228-234.

Research output: Contribution to journalArticle

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