Oral HIV/AIDS research alliance

Updated case definitions of oral disease endpoints

C. H. Shiboski, L. L. Patton, J. Y. Webster-Cyriaque, D. Greenspan, R. S. Traboulsi, M. Ghannoum, R. Jurevic, J. A. Phelan, D. Reznik, J. S. Greenspan

Research output: Contribution to journalArticle

Abstract

The Oral HIV/AIDS Research Alliance (OHARA) is part of the AIDS Clinical Trials Group (ACTG), the largest HIV clinical trials organization in the world. Its main objective is to investigate oral complications associated with HIV/AIDS as the epidemic is evolving, in particular, the effects of antiretrovirals on oral mucosal lesion development and associated fungal and viral pathogens. The OHARA infrastructure comprises: the Epidemiologic Research Unit (at the University of California San Francisco), the Medical Mycology Unit (at Case Western Reserve University) and the Virology/Specimen Banking Unit (at the University of North Carolina). The team includes dentists, physicians, virologists, mycologists, immunologists, epidemiologists and statisticians. Observational studies and clinical trials are being implemented at ACTG-affiliated sites in the US and resource-poor countries. Many studies have shared end-points, which include oral diseases known to be associated with HIV/AIDS measured by trained and calibrated ACTG study nurses. In preparation for future protocols, we have updated existing diagnostic criteria of the oral manifestations of HIV published in 1992 and 1993. The proposed case definitions are designed to be used in large-scale epidemiologic studies and clinical trials, in both US and resource-poor settings, where diagnoses may be made by non-dental healthcare providers. The objective of this article is to present updated case definitions for HIV-related oral diseases that will be used to measure standardized clinical end-points in OHARA studies, and that can be used by any investigator outside of OHARA/ACTG conducting clinical research that pertains to these end-points.

Original languageEnglish (US)
Pages (from-to)481-488
Number of pages8
JournalJournal of Oral Pathology and Medicine
Volume38
Issue number6
DOIs
StatePublished - Jul 2009

Fingerprint

Mouth Diseases
Acquired Immunodeficiency Syndrome
HIV
Clinical Trials
Research
Mycology
Oral Manifestations
Virology
San Francisco
Dentists
Health Personnel
Observational Studies
Epidemiologic Studies

Keywords

  • AIDS
  • Epidemiology
  • HIV
  • Oral lesions

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oral Surgery
  • Periodontics

Cite this

Shiboski, C. H., Patton, L. L., Webster-Cyriaque, J. Y., Greenspan, D., Traboulsi, R. S., Ghannoum, M., ... Greenspan, J. S. (2009). Oral HIV/AIDS research alliance: Updated case definitions of oral disease endpoints. Journal of Oral Pathology and Medicine, 38(6), 481-488. https://doi.org/10.1111/j.1600-0714.2009.00749.x

Oral HIV/AIDS research alliance : Updated case definitions of oral disease endpoints. / Shiboski, C. H.; Patton, L. L.; Webster-Cyriaque, J. Y.; Greenspan, D.; Traboulsi, R. S.; Ghannoum, M.; Jurevic, R.; Phelan, J. A.; Reznik, D.; Greenspan, J. S.

In: Journal of Oral Pathology and Medicine, Vol. 38, No. 6, 07.2009, p. 481-488.

Research output: Contribution to journalArticle

Shiboski, CH, Patton, LL, Webster-Cyriaque, JY, Greenspan, D, Traboulsi, RS, Ghannoum, M, Jurevic, R, Phelan, JA, Reznik, D & Greenspan, JS 2009, 'Oral HIV/AIDS research alliance: Updated case definitions of oral disease endpoints', Journal of Oral Pathology and Medicine, vol. 38, no. 6, pp. 481-488. https://doi.org/10.1111/j.1600-0714.2009.00749.x
Shiboski CH, Patton LL, Webster-Cyriaque JY, Greenspan D, Traboulsi RS, Ghannoum M et al. Oral HIV/AIDS research alliance: Updated case definitions of oral disease endpoints. Journal of Oral Pathology and Medicine. 2009 Jul;38(6):481-488. https://doi.org/10.1111/j.1600-0714.2009.00749.x
Shiboski, C. H. ; Patton, L. L. ; Webster-Cyriaque, J. Y. ; Greenspan, D. ; Traboulsi, R. S. ; Ghannoum, M. ; Jurevic, R. ; Phelan, J. A. ; Reznik, D. ; Greenspan, J. S. / Oral HIV/AIDS research alliance : Updated case definitions of oral disease endpoints. In: Journal of Oral Pathology and Medicine. 2009 ; Vol. 38, No. 6. pp. 481-488.
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