Oral epithelial overexpression of IL-1α causes periodontal disease

S. Dayan, P. Stashenko, Richard Niederman, T. S. Kupper

Research output: Contribution to journalArticle

Abstract

Periodontal disease is a bacterial infection that results in inflammatory destruction of tissues that support the teeth, including connective tissue and bone. In this study, we report that transgenic mice that overexpress the 17-kDa form of IL-1α in the basal layer of oral mucosal epithelium develop a syndrome that possesses all of the cardinal features of periodontal disease, including epithelial proliferation and apical migration, loss of attachment, and destruction of cementum and alveolar bone. In this model, bacterial colonization and infection were not required, since levels of periodontal bacteria were equivalent in transgenic and wild-type mice, and continuous treatment with antibiotics from birth did not ameliorate the disease. Our findings therefore indicate that elevated levels of IL-1α in the oral microenvironment can mediate all of the clinical features of periodontal disease.

Original languageEnglish (US)
Pages (from-to)786-790
Number of pages5
JournalJournal of Dental Research
Volume83
Issue number10
StatePublished - Oct 2004

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Periodontal Diseases
Interleukin-1
Bacterial Infections
Transgenic Mice
Dental Cementum
Bone and Bones
Connective Tissue
Tooth
Epithelium
Parturition
Anti-Bacterial Agents
Bacteria
Therapeutics

Keywords

  • Inflammation
  • Interleukin-1α
  • Mucosa
  • Periodontitis
  • Transgenic

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Oral epithelial overexpression of IL-1α causes periodontal disease. / Dayan, S.; Stashenko, P.; Niederman, Richard; Kupper, T. S.

In: Journal of Dental Research, Vol. 83, No. 10, 10.2004, p. 786-790.

Research output: Contribution to journalArticle

Dayan, S, Stashenko, P, Niederman, R & Kupper, TS 2004, 'Oral epithelial overexpression of IL-1α causes periodontal disease', Journal of Dental Research, vol. 83, no. 10, pp. 786-790.
Dayan, S. ; Stashenko, P. ; Niederman, Richard ; Kupper, T. S. / Oral epithelial overexpression of IL-1α causes periodontal disease. In: Journal of Dental Research. 2004 ; Vol. 83, No. 10. pp. 786-790.
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