Oral complications at 6 months after radiation therapy for head and neck cancer

for the OraRad Study Group

Research output: Contribution to journalArticle

Abstract

Objective: To examine oral complications 6 months after modern radiation therapy (RT) for head and neck cancer (HNC). Methods: Prospective multicenter cohort study of patients with HNC receiving intensity-modulated radiation therapy or more advanced RT. Stimulated whole salivary flow, maximal mouth opening, oral mucositis, oral pain, oral health-related quality of life (OH-QOL), and oral hygiene practices were measured in 372 subjects pre-RT and 216 subjects at 6 months from the start of RT. Results: Mean stimulated whole salivary flow declined from 1.09 to 0.47 ml/min at 6 months (p <.0001). Mean maximal mouth opening reduced from 45.58 to 42.53 mm at 6 months (p <.0001). 8.1% of subjects had some oral mucositis at 6 months, including 3.8% with oral ulceration. Mean overall pain score was unchanged. OH-QOL was reduced at 6 months, with changes related to dry mouth, sticky saliva, swallowing solid foods, and sense of taste (p ≤.0001). At 6 months, there was greater frequency of using dental floss and greater proportion using supplemental fluoride (p <.0001). Conclusions: Despite advances in RT techniques, patients with HNC experience oral complications 6 months after RT, with resulting negative impacts on oral function and quality of life.

Original languageEnglish (US)
Pages (from-to)1134-1143
Number of pages10
JournalOral Diseases
Volume23
Issue number8
DOIs
StatePublished - Nov 1 2017

Fingerprint

Head and Neck Neoplasms
Radiotherapy
Mouth
Stomatitis
Quality of Life
Oral Health
Home Care Dental Devices
Pain
Oral Hygiene
Mouth Neoplasms
Deglutition
Fluorides
Saliva
Multicenter Studies
Cohort Studies
Food

Keywords

  • head and neck cancer
  • mouth opening
  • oral complications
  • quality of life
  • radiation therapy
  • salivary flow

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Oral complications at 6 months after radiation therapy for head and neck cancer. / for the OraRad Study Group.

In: Oral Diseases, Vol. 23, No. 8, 01.11.2017, p. 1134-1143.

Research output: Contribution to journalArticle

for the OraRad Study Group. / Oral complications at 6 months after radiation therapy for head and neck cancer. In: Oral Diseases. 2017 ; Vol. 23, No. 8. pp. 1134-1143.
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