Oral Cancer: Genetics and the Role of Precision Medicine

Chia Cheng Li, Zhen Shen, Roxanne Bavarian, Fan Yang, Aditi Bhattacharya

Research output: Contribution to journalReview article

Abstract

Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world. OSCC patients are managed with surgery and/or chemoradiation. Prognoses and survival rates are dismal, however, and have not improved for more than 20 years. Recently, the concept of precision medicine was introduced, and the introduction of targeted therapeutics demonstrated promising outcomes. This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives. In addition, the applications and integration of omics technologies in biomarker discovery and drug development for treating OSCC are reviewed.

Original languageEnglish (US)
Pages (from-to)29-46
Number of pages18
JournalDental Clinics of North America
Volume62
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Precision Medicine
Mouth Neoplasms
Squamous Cell Carcinoma
Drug Discovery
Epigenomics
Survival Rate
Biomarkers
Neoplasm Metastasis
Technology
Neoplasms
Therapeutics

Keywords

  • Big data
  • Epigenetics
  • Malignant transformation
  • Omics technology
  • Oral cancer
  • Oral squamous cell carcinoma
  • Personalized medicine
  • Precision medicine

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Oral Cancer : Genetics and the Role of Precision Medicine. / Li, Chia Cheng; Shen, Zhen; Bavarian, Roxanne; Yang, Fan; Bhattacharya, Aditi.

In: Dental Clinics of North America, Vol. 62, No. 1, 01.01.2018, p. 29-46.

Research output: Contribution to journalReview article

Li, Chia Cheng ; Shen, Zhen ; Bavarian, Roxanne ; Yang, Fan ; Bhattacharya, Aditi. / Oral Cancer : Genetics and the Role of Precision Medicine. In: Dental Clinics of North America. 2018 ; Vol. 62, No. 1. pp. 29-46.
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