Optical mapping and its potential for large-scale sequencing projects

Christopher Aston, Bhubaneswar Mishra, David C. Schwartz

Research output: Contribution to journalArticle

Abstract

Physical mapping has been rediscovered as an important component of large-scale sequencing projects. Restriction maps provide landmark sequences at defined intervals, and high-resolution restriction maps can be assembled from ensembles of single molecules by optical means. Such optical maps can be constructed from both large-insert clones and genomic DNA, and are used as a scaffold for accurately aligning sequence contigs generated by shotgun sequencing. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalTrends in Biotechnology
Volume17
Issue number7
DOIs
StatePublished - Jul 1 1999

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Optical mapping and its potential for large-scale sequencing projects. / Aston, Christopher; Mishra, Bhubaneswar; Schwartz, David C.

In: Trends in Biotechnology, Vol. 17, No. 7, 01.07.1999, p. 297-302.

Research output: Contribution to journalArticle

Aston, Christopher ; Mishra, Bhubaneswar ; Schwartz, David C. / Optical mapping and its potential for large-scale sequencing projects. In: Trends in Biotechnology. 1999 ; Vol. 17, No. 7. pp. 297-302.
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