Optical control of TRPV1 channels

Marco Stein, Andreas Breit, Timm Fehrentz, Thomas Gudermann, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

Controlling pain with light: TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light-dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity.

Original languageEnglish (US)
Pages (from-to)9845-9848
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number37
DOIs
StatePublished - Sep 9 2013

Fingerprint

Capsaicin
Azobenzene
Ion Channels
Ions
azobenzene
Hot Temperature

Keywords

  • azobenzenes
  • capsaicin
  • capsazepine
  • photopharmacology
  • TRPV1

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Stein, M., Breit, A., Fehrentz, T., Gudermann, T., & Trauner, D. (2013). Optical control of TRPV1 channels. Angewandte Chemie - International Edition, 52(37), 9845-9848. https://doi.org/10.1002/anie.201302530

Optical control of TRPV1 channels. / Stein, Marco; Breit, Andreas; Fehrentz, Timm; Gudermann, Thomas; Trauner, Dirk.

In: Angewandte Chemie - International Edition, Vol. 52, No. 37, 09.09.2013, p. 9845-9848.

Research output: Contribution to journalArticle

Stein, M, Breit, A, Fehrentz, T, Gudermann, T & Trauner, D 2013, 'Optical control of TRPV1 channels', Angewandte Chemie - International Edition, vol. 52, no. 37, pp. 9845-9848. https://doi.org/10.1002/anie.201302530
Stein M, Breit A, Fehrentz T, Gudermann T, Trauner D. Optical control of TRPV1 channels. Angewandte Chemie - International Edition. 2013 Sep 9;52(37):9845-9848. https://doi.org/10.1002/anie.201302530
Stein, Marco ; Breit, Andreas ; Fehrentz, Timm ; Gudermann, Thomas ; Trauner, Dirk. / Optical control of TRPV1 channels. In: Angewandte Chemie - International Edition. 2013 ; Vol. 52, No. 37. pp. 9845-9848.
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