Optical control of L-type Ca2+ channels using a diltiazem photoswitch

Timm Fehrentz, Florian M.E. Huber, Nina Hartrampf, Tobias Bruegmann, James A. Frank, Nicholas H.F. Fine, Daniela Malan, Johann G. Danzl, Denis B. Tikhonov, Martin Sumser, Philipp Sasse, David J. Hodson, Boris S. Zhorov, Nikolaj Klöcker, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

L-type Ca2+ channels (LTCCs) play a crucial role in excitation-contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem, FHU-779, which can be used to reversibly block endogenous LTCCs by light. FHU-779 is as potent as diltiazem and can be used to place pancreatic β-cell function and cardiac activity under optical control.

Original languageEnglish (US)
Pages (from-to)764-767
Number of pages4
JournalNature Chemical Biology
Volume14
Issue number8
DOIs
StatePublished - Aug 1 2018

Fingerprint

Diltiazem
Optical Rotation
Excitation Contraction Coupling
Anti-Arrhythmia Agents
Antihypertensive Agents
Hormones
Light

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Fehrentz, T., Huber, F. M. E., Hartrampf, N., Bruegmann, T., Frank, J. A., Fine, N. H. F., ... Trauner, D. (2018). Optical control of L-type Ca2+ channels using a diltiazem photoswitch. Nature Chemical Biology, 14(8), 764-767. https://doi.org/10.1038/s41589-018-0090-8

Optical control of L-type Ca2+ channels using a diltiazem photoswitch. / Fehrentz, Timm; Huber, Florian M.E.; Hartrampf, Nina; Bruegmann, Tobias; Frank, James A.; Fine, Nicholas H.F.; Malan, Daniela; Danzl, Johann G.; Tikhonov, Denis B.; Sumser, Martin; Sasse, Philipp; Hodson, David J.; Zhorov, Boris S.; Klöcker, Nikolaj; Trauner, Dirk.

In: Nature Chemical Biology, Vol. 14, No. 8, 01.08.2018, p. 764-767.

Research output: Contribution to journalArticle

Fehrentz, T, Huber, FME, Hartrampf, N, Bruegmann, T, Frank, JA, Fine, NHF, Malan, D, Danzl, JG, Tikhonov, DB, Sumser, M, Sasse, P, Hodson, DJ, Zhorov, BS, Klöcker, N & Trauner, D 2018, 'Optical control of L-type Ca2+ channels using a diltiazem photoswitch', Nature Chemical Biology, vol. 14, no. 8, pp. 764-767. https://doi.org/10.1038/s41589-018-0090-8
Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF et al. Optical control of L-type Ca2+ channels using a diltiazem photoswitch. Nature Chemical Biology. 2018 Aug 1;14(8):764-767. https://doi.org/10.1038/s41589-018-0090-8
Fehrentz, Timm ; Huber, Florian M.E. ; Hartrampf, Nina ; Bruegmann, Tobias ; Frank, James A. ; Fine, Nicholas H.F. ; Malan, Daniela ; Danzl, Johann G. ; Tikhonov, Denis B. ; Sumser, Martin ; Sasse, Philipp ; Hodson, David J. ; Zhorov, Boris S. ; Klöcker, Nikolaj ; Trauner, Dirk. / Optical control of L-type Ca2+ channels using a diltiazem photoswitch. In: Nature Chemical Biology. 2018 ; Vol. 14, No. 8. pp. 764-767.
@article{1dade6500dd043d3b07594fc5e8563d1,
title = "Optical control of L-type Ca2+ channels using a diltiazem photoswitch",
abstract = "L-type Ca2+ channels (LTCCs) play a crucial role in excitation-contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem, FHU-779, which can be used to reversibly block endogenous LTCCs by light. FHU-779 is as potent as diltiazem and can be used to place pancreatic β-cell function and cardiac activity under optical control.",
author = "Timm Fehrentz and Huber, {Florian M.E.} and Nina Hartrampf and Tobias Bruegmann and Frank, {James A.} and Fine, {Nicholas H.F.} and Daniela Malan and Danzl, {Johann G.} and Tikhonov, {Denis B.} and Martin Sumser and Philipp Sasse and Hodson, {David J.} and Zhorov, {Boris S.} and Nikolaj Kl{\"o}cker and Dirk Trauner",
year = "2018",
month = "8",
day = "1",
doi = "10.1038/s41589-018-0090-8",
language = "English (US)",
volume = "14",
pages = "764--767",
journal = "Nature Chemical Biology",
issn = "1552-4450",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Optical control of L-type Ca2+ channels using a diltiazem photoswitch

AU - Fehrentz, Timm

AU - Huber, Florian M.E.

AU - Hartrampf, Nina

AU - Bruegmann, Tobias

AU - Frank, James A.

AU - Fine, Nicholas H.F.

AU - Malan, Daniela

AU - Danzl, Johann G.

AU - Tikhonov, Denis B.

AU - Sumser, Martin

AU - Sasse, Philipp

AU - Hodson, David J.

AU - Zhorov, Boris S.

AU - Klöcker, Nikolaj

AU - Trauner, Dirk

PY - 2018/8/1

Y1 - 2018/8/1

N2 - L-type Ca2+ channels (LTCCs) play a crucial role in excitation-contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem, FHU-779, which can be used to reversibly block endogenous LTCCs by light. FHU-779 is as potent as diltiazem and can be used to place pancreatic β-cell function and cardiac activity under optical control.

AB - L-type Ca2+ channels (LTCCs) play a crucial role in excitation-contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem, FHU-779, which can be used to reversibly block endogenous LTCCs by light. FHU-779 is as potent as diltiazem and can be used to place pancreatic β-cell function and cardiac activity under optical control.

UR - http://www.scopus.com/inward/record.url?scp=85050281168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050281168&partnerID=8YFLogxK

U2 - 10.1038/s41589-018-0090-8

DO - 10.1038/s41589-018-0090-8

M3 - Article

VL - 14

SP - 764

EP - 767

JO - Nature Chemical Biology

JF - Nature Chemical Biology

SN - 1552-4450

IS - 8

ER -