Opponent interactions between serotonin and dopamine

Nathaniel D. Daw, Sham Kakade, Peter Dayan

Research output: Contribution to journalArticle

Abstract

Anatomical and pharmacological evidence suggests that the dorsal raphe serotonin system and the ventral tegmental and substantia nigra dopamine system may act as mutual opponents. In the light of the temporal difference model of the involvement of the dopamine system in reward learning, we consider three aspects of motivational opponency involving dopamine and serotonin. We suggest that a tonic serotonergic signal reports the long-run average reward rate as part of an average-case reinforcement learning model; that a tonic dopaminergic signal reports the long-run average punishment rate in a similar context; and finally speculate that a phasic serotonin signal might report an ongoing prediction error for future punishment.

Original languageEnglish (US)
Pages (from-to)603-616
Number of pages14
JournalNeural Networks
Volume15
Issue number4-6
DOIs
StatePublished - Jun 2002

Fingerprint

Dopamine
Serotonin
Punishment
Reward
Learning
Reinforcement learning
Substantia Nigra
Pharmacology
Dorsal Raphe Nucleus
Reinforcement (Psychology)

Keywords

  • Aversion
  • Dopamine
  • Opponency
  • Punishment
  • Reinforcement learning
  • Reward
  • Serotonin
  • Solomon-Corbit

ASJC Scopus subject areas

  • Artificial Intelligence
  • Neuroscience(all)

Cite this

Opponent interactions between serotonin and dopamine. / Daw, Nathaniel D.; Kakade, Sham; Dayan, Peter.

In: Neural Networks, Vol. 15, No. 4-6, 06.2002, p. 603-616.

Research output: Contribution to journalArticle

Daw, Nathaniel D. ; Kakade, Sham ; Dayan, Peter. / Opponent interactions between serotonin and dopamine. In: Neural Networks. 2002 ; Vol. 15, No. 4-6. pp. 603-616.
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