Onset of Cell Proliferation in the Shortened Gut: Colonic hyperplasia after ileal resection

Samiran Nundy, Daniel Malamud, Huug Obertop, Jerzy Sczerban, Ronald A. Malt

Research output: Contribution to journalArticle

Abstract

Cytokinetics in colonic mucosa were studied after ileal resection in young female rats. The RNA content of the transverse colon was increased 32% after 7 days; after 14 days the increase was present throughout the colon. The DNA content of the ascending colon increased 29% after 10 days. Specific activity of DNA labeled with [3H-methyl]thymidine was elevated 29% in the ascending colon and elevated 49% in the descending colon on the 7th postoperative day. Colonic cell proliferation is stimulated within 1 week of ileal resection.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalGastroenterology
Volume72
Issue number2
DOIs
StatePublished - Jan 1 1977

    Fingerprint

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this