On the toroidal condensed state of closed circular DNA

A. Y. Grosberg, A. V. Zhestkov

    Research output: Contribution to journalArticle

    Abstract

    The influence of double helix torsional elasticity on the compaction and structure of circular DNA compact form is studied theoretically in the case when the compact (globular) form has torus shape. For closed circular DNA the topological invariant, the linking number, yields a strict connection between conformation of the double helix considered as unifilar homopolymer and elastic energy of torsional twisting. The contribution of torsional elasticity to free energy of the toruslike globule is calculated. This contribution is shown to be proportional to the square of superhelical density. Allowance of the torsional elasticity decreases the equilibrium radius of the toruslike globule formed by circular DNA. Closure of linear DNA into a ring widens the stability range of the relatively short DNA compact form and tightens it for long DNA.

    Original languageEnglish (US)
    Pages (from-to)515-520
    Number of pages6
    JournalJournal of Biomolecular Structure and Dynamics
    Volume3
    Issue number3
    StatePublished - 1985

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    Circular DNA
    Elasticity
    DNA

    ASJC Scopus subject areas

    • Molecular Biology
    • Structural Biology

    Cite this

    On the toroidal condensed state of closed circular DNA. / Grosberg, A. Y.; Zhestkov, A. V.

    In: Journal of Biomolecular Structure and Dynamics, Vol. 3, No. 3, 1985, p. 515-520.

    Research output: Contribution to journalArticle

    Grosberg, AY & Zhestkov, AV 1985, 'On the toroidal condensed state of closed circular DNA', Journal of Biomolecular Structure and Dynamics, vol. 3, no. 3, pp. 515-520.
    Grosberg, A. Y. ; Zhestkov, A. V. / On the toroidal condensed state of closed circular DNA. In: Journal of Biomolecular Structure and Dynamics. 1985 ; Vol. 3, No. 3. pp. 515-520.
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