On the origins of tandemly repeated genes: Does histone gene copy number in Drosophila reflect chromosomal location?

David Fitch, Linda D. Strausbaugh, Victoria Barrett

Research output: Contribution to journalArticle

Abstract

Widely regarded beliefs about Drosophila histone gene copy numbers and developmental requirements have been generalized from fairly limited data since studies on histone gene arrangements and copy numbers have been largely confined to a single species, D. melanogaster. Histone gene copy numbers and chromosomal locations were examined in three species:D. melanogaster, D. hydei and D. hawaiiensis. Quantitative whole genome blot analysis of DNA from diploid tissues revealed a tenfold variability in histone gene copy numbers for these three species. In situ hybridization to polytene chromosomes showed that the histone DNA (hDNA) chromosomal location is different in all three species. These observations lead us to propose a relationship between histone gene reiteration and chromosomal position.

Original languageEnglish (US)
Pages (from-to)118-124
Number of pages7
JournalChromosoma
Volume99
Issue number2
DOIs
StatePublished - Apr 1990

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Gene Dosage
Histones
Drosophila
Genes
Polytene Chromosomes
Gene Order
DNA
Diploidy
In Situ Hybridization
Genome

ASJC Scopus subject areas

  • Genetics

Cite this

On the origins of tandemly repeated genes : Does histone gene copy number in Drosophila reflect chromosomal location? / Fitch, David; Strausbaugh, Linda D.; Barrett, Victoria.

In: Chromosoma, Vol. 99, No. 2, 04.1990, p. 118-124.

Research output: Contribution to journalArticle

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