On the helix-coil transition in heterogeneous polymers

D. M. Crothers, N. R. Kallenbach

Research output: Contribution to journalArticle

Abstract

A general theory for the helix-coil transition of block copolymers of regularly alternating sequence, applicable in principle to both nucleic acids and polypeptides, is developed. The stability of helical regions of the molecule is permitted to vary depending on the nature of the monomers in that section. Calculations are reported for DNA-like molecules. The approximation is then made that a molecule of random sequence can be treated as a linear combination of block copolymers of varying block size, and on this basis the average length of correlations in the state of neighboring base pairs in a natural DNA which is undergoing transition is estimated to be about 1400 base pairs. An approximate model for DNA melting developed on these grounds yields a transition curve in satisfactory agreement with experiment.

Original languageEnglish (US)
Pages (from-to)917-927
Number of pages11
JournalThe Journal of chemical physics
Volume45
Issue number3
StatePublished - 1966

Fingerprint

helices
Polymers
coils
deoxyribonucleic acid
block copolymers
Block copolymers
Molecules
DNA
polymers
molecules
polypeptides
nucleic acids
Nucleic Acids
Melting
monomers
Monomers
melting
Peptides
curves
approximation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Crothers, D. M., & Kallenbach, N. R. (1966). On the helix-coil transition in heterogeneous polymers. The Journal of chemical physics, 45(3), 917-927.

On the helix-coil transition in heterogeneous polymers. / Crothers, D. M.; Kallenbach, N. R.

In: The Journal of chemical physics, Vol. 45, No. 3, 1966, p. 917-927.

Research output: Contribution to journalArticle

Crothers, DM & Kallenbach, NR 1966, 'On the helix-coil transition in heterogeneous polymers', The Journal of chemical physics, vol. 45, no. 3, pp. 917-927.
Crothers, D. M. ; Kallenbach, N. R. / On the helix-coil transition in heterogeneous polymers. In: The Journal of chemical physics. 1966 ; Vol. 45, No. 3. pp. 917-927.
@article{c0e880b1045549419b65c66145d8042d,
title = "On the helix-coil transition in heterogeneous polymers",
abstract = "A general theory for the helix-coil transition of block copolymers of regularly alternating sequence, applicable in principle to both nucleic acids and polypeptides, is developed. The stability of helical regions of the molecule is permitted to vary depending on the nature of the monomers in that section. Calculations are reported for DNA-like molecules. The approximation is then made that a molecule of random sequence can be treated as a linear combination of block copolymers of varying block size, and on this basis the average length of correlations in the state of neighboring base pairs in a natural DNA which is undergoing transition is estimated to be about 1400 base pairs. An approximate model for DNA melting developed on these grounds yields a transition curve in satisfactory agreement with experiment.",
author = "Crothers, {D. M.} and Kallenbach, {N. R.}",
year = "1966",
language = "English (US)",
volume = "45",
pages = "917--927",
journal = "Journal of Chemical Physics",
issn = "0021-9606",
publisher = "American Institute of Physics Publising LLC",
number = "3",

}

TY - JOUR

T1 - On the helix-coil transition in heterogeneous polymers

AU - Crothers, D. M.

AU - Kallenbach, N. R.

PY - 1966

Y1 - 1966

N2 - A general theory for the helix-coil transition of block copolymers of regularly alternating sequence, applicable in principle to both nucleic acids and polypeptides, is developed. The stability of helical regions of the molecule is permitted to vary depending on the nature of the monomers in that section. Calculations are reported for DNA-like molecules. The approximation is then made that a molecule of random sequence can be treated as a linear combination of block copolymers of varying block size, and on this basis the average length of correlations in the state of neighboring base pairs in a natural DNA which is undergoing transition is estimated to be about 1400 base pairs. An approximate model for DNA melting developed on these grounds yields a transition curve in satisfactory agreement with experiment.

AB - A general theory for the helix-coil transition of block copolymers of regularly alternating sequence, applicable in principle to both nucleic acids and polypeptides, is developed. The stability of helical regions of the molecule is permitted to vary depending on the nature of the monomers in that section. Calculations are reported for DNA-like molecules. The approximation is then made that a molecule of random sequence can be treated as a linear combination of block copolymers of varying block size, and on this basis the average length of correlations in the state of neighboring base pairs in a natural DNA which is undergoing transition is estimated to be about 1400 base pairs. An approximate model for DNA melting developed on these grounds yields a transition curve in satisfactory agreement with experiment.

UR - http://www.scopus.com/inward/record.url?scp=0038415527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038415527&partnerID=8YFLogxK

M3 - Article

VL - 45

SP - 917

EP - 927

JO - Journal of Chemical Physics

JF - Journal of Chemical Physics

SN - 0021-9606

IS - 3

ER -