Abstract
The dentate gyrus (DG) is crucial for behaviorally discriminating similar spatial memories, predicting that DG place cells change (“remap”) their relative spatial tuning (“place fields”) for memory discrimination. This prediction was never tested, although DG place cells remap across similar environments without memory tasks. We confirm this prior finding but find that DG place fields do not remap across spatial tasks that require DG-dependent memory discrimination. Instead of remapping, place-discriminating discharge is observed transiently among DG place cells, particularly when memory discrimination is most necessary. The DG network may signal memory discrimination by expressing distinctive sub-second network patterns of co-firing at memory discrimination sites. This involves increased coupling of discharge from place cells and interneurons, as was observed during successful, but not failed, behavioral expression of memory discrimination. Instead of remapping, these findings indicate that memory discrimination is signaled by sub-second patterns of correlated discharge within the dentate network. van Dijk and Fenton report that dentate gyrus place cells signal memory discrimination not by remapping, but by variable sub-second patterns of coordinated place cell discharge marked by enhanced discharge coupling between excitatory and inhibitory neurons during memory discrimination.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 832-845.e5 |
| Journal | Neuron |
| Volume | 98 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 16 2018 |
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Keywords
- dentate gyrus
- memory discrimination
- pattern separation
- place cells
- remapping
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
On How the Dentate Gyrus Contributes to Memory Discrimination. / van Dijk, Milenna Tamara; Fenton, Andre.
In: Neuron, Vol. 98, No. 4, 16.05.2018, p. 832-845.e5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - On How the Dentate Gyrus Contributes to Memory Discrimination
AU - van Dijk, Milenna Tamara
AU - Fenton, Andre
PY - 2018/5/16
Y1 - 2018/5/16
N2 - The dentate gyrus (DG) is crucial for behaviorally discriminating similar spatial memories, predicting that DG place cells change (“remap”) their relative spatial tuning (“place fields”) for memory discrimination. This prediction was never tested, although DG place cells remap across similar environments without memory tasks. We confirm this prior finding but find that DG place fields do not remap across spatial tasks that require DG-dependent memory discrimination. Instead of remapping, place-discriminating discharge is observed transiently among DG place cells, particularly when memory discrimination is most necessary. The DG network may signal memory discrimination by expressing distinctive sub-second network patterns of co-firing at memory discrimination sites. This involves increased coupling of discharge from place cells and interneurons, as was observed during successful, but not failed, behavioral expression of memory discrimination. Instead of remapping, these findings indicate that memory discrimination is signaled by sub-second patterns of correlated discharge within the dentate network. van Dijk and Fenton report that dentate gyrus place cells signal memory discrimination not by remapping, but by variable sub-second patterns of coordinated place cell discharge marked by enhanced discharge coupling between excitatory and inhibitory neurons during memory discrimination.
AB - The dentate gyrus (DG) is crucial for behaviorally discriminating similar spatial memories, predicting that DG place cells change (“remap”) their relative spatial tuning (“place fields”) for memory discrimination. This prediction was never tested, although DG place cells remap across similar environments without memory tasks. We confirm this prior finding but find that DG place fields do not remap across spatial tasks that require DG-dependent memory discrimination. Instead of remapping, place-discriminating discharge is observed transiently among DG place cells, particularly when memory discrimination is most necessary. The DG network may signal memory discrimination by expressing distinctive sub-second network patterns of co-firing at memory discrimination sites. This involves increased coupling of discharge from place cells and interneurons, as was observed during successful, but not failed, behavioral expression of memory discrimination. Instead of remapping, these findings indicate that memory discrimination is signaled by sub-second patterns of correlated discharge within the dentate network. van Dijk and Fenton report that dentate gyrus place cells signal memory discrimination not by remapping, but by variable sub-second patterns of coordinated place cell discharge marked by enhanced discharge coupling between excitatory and inhibitory neurons during memory discrimination.
KW - dentate gyrus
KW - memory discrimination
KW - pattern separation
KW - place cells
KW - remapping
UR - http://www.scopus.com/inward/record.url?scp=85046369890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046369890&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2018.04.018
DO - 10.1016/j.neuron.2018.04.018
M3 - Article
VL - 98
SP - 832-845.e5
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 4
ER -