On a novel coalescent model for genome-wide evolution of copy number variations

Antonina Mitrofanova, Bhubaneswar Mishra

Research output: Contribution to journalArticle

Abstract

Since we are limited in our knowledge of human demographic history and variations of recombination and mutation rates, large-scale computer simulation is a necessary tool in genetics. Here we propose and computationally simulate a model of evolution for unique and segmentally duplicated regions of human genome. Since such segmentally duplicated regions show a complex behaviour of copy number changes, our model will hopefully lead to a better understanding of the evolutionary developments of CNVs, algorithms for associations studies with CNV markers, and finally, for characterising parameters for stochastic diffusion models, describing asymptotic behaviour of evolutionary processes.

Original languageEnglish (US)
Pages (from-to)300-315
Number of pages16
JournalInternational Journal of Data Mining and Bioinformatics
Volume4
Issue number3
DOIs
StatePublished - Jun 2010

Keywords

  • CNVs
  • Coalescent process
  • Copy number polymorphism
  • Copy number variations
  • SDs
  • Segmental duplications

ASJC Scopus subject areas

  • Information Systems
  • Biochemistry, Genetics and Molecular Biology(all)
  • Library and Information Sciences

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