Oligophenylenaminones as scaffolds for α-helix mimicry

Marc J. Adler, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

The design and synthesis of small molecule α-helix mimetics has been a productive field over the past decade. These compounds have performed well in a variety of biological systems as functional disruptors of α-helix- mediated protein-protein interactions. In our studies we have continued to develop novel, more biologically compatible scaffolds, which are often easier to assemble and capable of mimicking longer and/or more diverse helices. To this end, we have constructed a new series of i, i+4, i+7 α-helix mimics based on the enaminone scaffold. These molecules represent a step forward in the pursuit of idealized monofacial α-helix mimetics.

Original languageEnglish (US)
Pages (from-to)7040-7047
Number of pages8
JournalJournal of Organic Chemistry
Volume76
Issue number17
DOIs
StatePublished - Sep 2 2011

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ASJC Scopus subject areas

  • Organic Chemistry

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