Oligooxopiperazines as nonpeptidic α-helix mimetics

Petra Tošovská, Paramjit Arora

Research output: Contribution to journalArticle

Abstract

Chemical Reaction Repretatio A new class of nonpeptidic α-helix mlmetics derived from a-amino acids and featuring chlral backbones is described. NMR and circular dichroism spectroscopies, in combination with molecular modeling studies, provide compelling evidence that ollgooxopiperazlne dimers adopt stable conformations that reproduce the arrangement of i, i+4, and i+7 residues on an α-helix.

Original languageEnglish (US)
Pages (from-to)1588-1591
Number of pages4
JournalOrganic Letters
Volume12
Issue number7
DOIs
StatePublished - Apr 2 2010

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Circular dichroism spectroscopy
Molecular modeling
Circular Dichroism
Dimers
helices
Conformations
Chemical reactions
Spectrum Analysis
Nuclear magnetic resonance
Amino Acids
dichroism
amino acids
chemical reactions
dimers
nuclear magnetic resonance
spectroscopy

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Oligooxopiperazines as nonpeptidic α-helix mimetics. / Tošovská, Petra; Arora, Paramjit.

In: Organic Letters, Vol. 12, No. 7, 02.04.2010, p. 1588-1591.

Research output: Contribution to journalArticle

Tošovská, Petra ; Arora, Paramjit. / Oligooxopiperazines as nonpeptidic α-helix mimetics. In: Organic Letters. 2010 ; Vol. 12, No. 7. pp. 1588-1591.
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