Olfactory bulb habituation to odor stimuli

Dipesh Chaudhury, Laura Manella, Adolfo Arellanos, Olga Escanilla, Thomas A. Cleland, Christiane Linster

    Research output: Contribution to journalArticle

    Abstract

    Habituation is a simple form of memory, yet its neurobiological mechanisms are only beginning to be understood in mammals. In the olfactory system, the neural correlates of habituation at a fast experimental timescale involving very short intertrial intervals (tens of seconds) have been shown to depend on synaptic adaptation in olfactory cortex. In contrast, behavioral habituation to odorants on a longer timescale with intertrial intervals of several minutes depends on processes in the olfactory bulb, as demonstrated by pharmacological studies. We here show that behavioral habituation to odorants on this longer timescale has a neuronal activity correlate in the olfactory bulb. Spiking responses of mitral cells in the rat olfactory bulb adapt to, and recover from, repeated odorant stimulation with 5-min intertrial intervals with a time course similar to that of behavioral habituation. Moreover, both the behavioral and neuronal effects of odor habituation require functioning N-methyl-d-aspartic acid receptors in the olfactory bulb.

    Original languageEnglish (US)
    Pages (from-to)490-499
    Number of pages10
    JournalBehavioral Neuroscience
    Volume124
    Issue number4
    DOIs
    StatePublished - Aug 1 2010

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    Olfactory Bulb
    Mammals
    Pharmacology
    Odorants

    Keywords

    • Adaptation
    • Bulb
    • Habituation
    • NMDA
    • Olfaction
    • Rodent

    ASJC Scopus subject areas

    • Behavioral Neuroscience

    Cite this

    Chaudhury, D., Manella, L., Arellanos, A., Escanilla, O., Cleland, T. A., & Linster, C. (2010). Olfactory bulb habituation to odor stimuli. Behavioral Neuroscience, 124(4), 490-499. https://doi.org/10.1037/a0020293

    Olfactory bulb habituation to odor stimuli. / Chaudhury, Dipesh; Manella, Laura; Arellanos, Adolfo; Escanilla, Olga; Cleland, Thomas A.; Linster, Christiane.

    In: Behavioral Neuroscience, Vol. 124, No. 4, 01.08.2010, p. 490-499.

    Research output: Contribution to journalArticle

    Chaudhury, D, Manella, L, Arellanos, A, Escanilla, O, Cleland, TA & Linster, C 2010, 'Olfactory bulb habituation to odor stimuli', Behavioral Neuroscience, vol. 124, no. 4, pp. 490-499. https://doi.org/10.1037/a0020293
    Chaudhury D, Manella L, Arellanos A, Escanilla O, Cleland TA, Linster C. Olfactory bulb habituation to odor stimuli. Behavioral Neuroscience. 2010 Aug 1;124(4):490-499. https://doi.org/10.1037/a0020293
    Chaudhury, Dipesh ; Manella, Laura ; Arellanos, Adolfo ; Escanilla, Olga ; Cleland, Thomas A. ; Linster, Christiane. / Olfactory bulb habituation to odor stimuli. In: Behavioral Neuroscience. 2010 ; Vol. 124, No. 4. pp. 490-499.
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