Olanzapine attenuates cue-elicited craving for tobacco

Kent E. Hutchison, Marie Christine Rutter, Raymond Niaura, Robert M. Swift, Wallace B. Pickworth, Laura Sobik

Research output: Contribution to journalArticle

Abstract

Rationale: Recent biological conceptualizations of craving and addiction have implicated mesolimbic dopamine activity as a central feature of the process of addiction. Imaging, and pharmacological studies have supported a role for dopaminergic structures in cue-elicited craving for tobacco. Objective: If mesolimbic dopamine activity is associated with cue-elicited craving for tobacco, a dopamine antagonist should attenuate cue-elicited craving for tobacco. Thus, the aim of the present study was to determine whether an atypical antipsychotic (olanzapine, 5 mg) decreased cue-elicited craving for tobacco. Method: Participants were randomly assigned to 5 days of pretreatment with olanzapine (5 mg; n=31) or were randomly assigned to 5 days of a matching placebo (n=28). Approximately 8 h after the last dose, participants were exposed to a control cue (pencil) followed by exposure to smoking cues. Participants subsequently smoked either nicotine cigarettes or de-nicotinized cigarettes. Results: Olanzapine attenuated cue-elicited craving for tobacco but did not moderate the subjective effects of smoking. Discussion: This study represents one of the first investigations of the effect of atypical antipsychotics on cue-elicited craving for tobacco. The results suggest that medications with similar profiles may reduce cue-elicited craving, which in turn, may partially explain recent observations that atypical antipsychotics may reduce substance use.

Original languageEnglish (US)
Pages (from-to)407-413
Number of pages7
JournalPsychopharmacology
Volume175
Issue number4
DOIs
StatePublished - Oct 2004

Fingerprint

olanzapine
Tobacco
Cues
Antipsychotic Agents
Tobacco Products
Dopamine
Smoking
Craving
Dopamine Antagonists
Nicotine

Keywords

  • Craving
  • Nicotine
  • Olanzapine
  • Smoking

ASJC Scopus subject areas

  • Pharmacology

Cite this

Hutchison, K. E., Rutter, M. C., Niaura, R., Swift, R. M., Pickworth, W. B., & Sobik, L. (2004). Olanzapine attenuates cue-elicited craving for tobacco. Psychopharmacology, 175(4), 407-413. https://doi.org/10.1007/s00213-004-1837-3

Olanzapine attenuates cue-elicited craving for tobacco. / Hutchison, Kent E.; Rutter, Marie Christine; Niaura, Raymond; Swift, Robert M.; Pickworth, Wallace B.; Sobik, Laura.

In: Psychopharmacology, Vol. 175, No. 4, 10.2004, p. 407-413.

Research output: Contribution to journalArticle

Hutchison, KE, Rutter, MC, Niaura, R, Swift, RM, Pickworth, WB & Sobik, L 2004, 'Olanzapine attenuates cue-elicited craving for tobacco', Psychopharmacology, vol. 175, no. 4, pp. 407-413. https://doi.org/10.1007/s00213-004-1837-3
Hutchison KE, Rutter MC, Niaura R, Swift RM, Pickworth WB, Sobik L. Olanzapine attenuates cue-elicited craving for tobacco. Psychopharmacology. 2004 Oct;175(4):407-413. https://doi.org/10.1007/s00213-004-1837-3
Hutchison, Kent E. ; Rutter, Marie Christine ; Niaura, Raymond ; Swift, Robert M. ; Pickworth, Wallace B. ; Sobik, Laura. / Olanzapine attenuates cue-elicited craving for tobacco. In: Psychopharmacology. 2004 ; Vol. 175, No. 4. pp. 407-413.
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