Odorant-induced and sniff-induced activation in the cerebellum of the human

Noam Sobel, Vivek Prabhakaran, Catherine Hartley, John E. Desmond, Zuo Zhao, Gary H. Glover, John D E Gabrieli, Edith V. Sullivan

Research output: Contribution to journalArticle

Abstract

Functional magnetic resonance imaging was used to test whether odorants induce activation in the cerebellum of the human. The odorants vanillin and propionic acid both induced significant activation, primarily in the posterior lateral hemispheres. Activation was concentration-dependent, greater after stimulation with higher concentration odorants. By contrast, the action of sniffing nonodorized air induced significant activation in the anterior cerebellum, primarily in the central lobule. These findings demonstrate that the cerebellum plays a role in human olfaction. A hypothesis is proposed whereby the cerebellum maintains a feedback mechanism that regulates sniff volume in relation to odor concentration.

Original languageEnglish (US)
Pages (from-to)8990-9001
Number of pages12
JournalJournal of Neuroscience
Volume18
Issue number21
StatePublished - Nov 1 1998

Fingerprint

Cerebellum
Smell
Air
Magnetic Resonance Imaging
Odorants

Keywords

  • Cerebellum
  • Human
  • Odor
  • Olfaction
  • Smell
  • Sniffing

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sobel, N., Prabhakaran, V., Hartley, C., Desmond, J. E., Zhao, Z., Glover, G. H., ... Sullivan, E. V. (1998). Odorant-induced and sniff-induced activation in the cerebellum of the human. Journal of Neuroscience, 18(21), 8990-9001.

Odorant-induced and sniff-induced activation in the cerebellum of the human. / Sobel, Noam; Prabhakaran, Vivek; Hartley, Catherine; Desmond, John E.; Zhao, Zuo; Glover, Gary H.; Gabrieli, John D E; Sullivan, Edith V.

In: Journal of Neuroscience, Vol. 18, No. 21, 01.11.1998, p. 8990-9001.

Research output: Contribution to journalArticle

Sobel, N, Prabhakaran, V, Hartley, C, Desmond, JE, Zhao, Z, Glover, GH, Gabrieli, JDE & Sullivan, EV 1998, 'Odorant-induced and sniff-induced activation in the cerebellum of the human', Journal of Neuroscience, vol. 18, no. 21, pp. 8990-9001.
Sobel N, Prabhakaran V, Hartley C, Desmond JE, Zhao Z, Glover GH et al. Odorant-induced and sniff-induced activation in the cerebellum of the human. Journal of Neuroscience. 1998 Nov 1;18(21):8990-9001.
Sobel, Noam ; Prabhakaran, Vivek ; Hartley, Catherine ; Desmond, John E. ; Zhao, Zuo ; Glover, Gary H. ; Gabrieli, John D E ; Sullivan, Edith V. / Odorant-induced and sniff-induced activation in the cerebellum of the human. In: Journal of Neuroscience. 1998 ; Vol. 18, No. 21. pp. 8990-9001.
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