Nylon/DNA: Single-stranded DNA with a covalently stitched nylon lining

Lei Zhu, Philip S. Lukeman, James Canary, Nadrian Seeman

Research output: Contribution to journalArticle

Abstract

The synthesis of DNA/nylon ladder oligomers is described. Three stages of the development are addressed: the synthesis of 2′-β-substituted phosphoramidites, the deprotection/purification protocols of ODNs modified with both amino and carboxyl groups, and amide bond-forming reactions on the ODNs. The established technology and the novel DNA-based ladder oligomer structure opens a pathway to the synthesis of topological molecular objects and networks templated by DNA through versatile DNA nanotechnology. The DNA-based ladder oligomers may find application in the antisense area.

Original languageEnglish (US)
Pages (from-to)10178-10179
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number34
DOIs
StatePublished - Aug 27 2003

Fingerprint

Single-Stranded DNA
Nylons
Linings
DNA
Ladders
Oligomers
Nanotechnology
Amides
Purification
Technology

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Nylon/DNA : Single-stranded DNA with a covalently stitched nylon lining. / Zhu, Lei; Lukeman, Philip S.; Canary, James; Seeman, Nadrian.

In: Journal of the American Chemical Society, Vol. 125, No. 34, 27.08.2003, p. 10178-10179.

Research output: Contribution to journalArticle

@article{8fa6988ae8f54943844009131e5c89e2,
title = "Nylon/DNA: Single-stranded DNA with a covalently stitched nylon lining",
abstract = "The synthesis of DNA/nylon ladder oligomers is described. Three stages of the development are addressed: the synthesis of 2′-β-substituted phosphoramidites, the deprotection/purification protocols of ODNs modified with both amino and carboxyl groups, and amide bond-forming reactions on the ODNs. The established technology and the novel DNA-based ladder oligomer structure opens a pathway to the synthesis of topological molecular objects and networks templated by DNA through versatile DNA nanotechnology. The DNA-based ladder oligomers may find application in the antisense area.",
author = "Lei Zhu and Lukeman, {Philip S.} and James Canary and Nadrian Seeman",
year = "2003",
month = "8",
day = "27",
doi = "10.1021/ja035186r",
language = "English (US)",
volume = "125",
pages = "10178--10179",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "34",

}

TY - JOUR

T1 - Nylon/DNA

T2 - Single-stranded DNA with a covalently stitched nylon lining

AU - Zhu, Lei

AU - Lukeman, Philip S.

AU - Canary, James

AU - Seeman, Nadrian

PY - 2003/8/27

Y1 - 2003/8/27

N2 - The synthesis of DNA/nylon ladder oligomers is described. Three stages of the development are addressed: the synthesis of 2′-β-substituted phosphoramidites, the deprotection/purification protocols of ODNs modified with both amino and carboxyl groups, and amide bond-forming reactions on the ODNs. The established technology and the novel DNA-based ladder oligomer structure opens a pathway to the synthesis of topological molecular objects and networks templated by DNA through versatile DNA nanotechnology. The DNA-based ladder oligomers may find application in the antisense area.

AB - The synthesis of DNA/nylon ladder oligomers is described. Three stages of the development are addressed: the synthesis of 2′-β-substituted phosphoramidites, the deprotection/purification protocols of ODNs modified with both amino and carboxyl groups, and amide bond-forming reactions on the ODNs. The established technology and the novel DNA-based ladder oligomer structure opens a pathway to the synthesis of topological molecular objects and networks templated by DNA through versatile DNA nanotechnology. The DNA-based ladder oligomers may find application in the antisense area.

UR - http://www.scopus.com/inward/record.url?scp=0041429646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041429646&partnerID=8YFLogxK

U2 - 10.1021/ja035186r

DO - 10.1021/ja035186r

M3 - Article

C2 - 12926933

AN - SCOPUS:0041429646

VL - 125

SP - 10178

EP - 10179

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 34

ER -