Numerical simulation and experimental validation of blood flow in arteries with structured-tree outflow conditions

Mette S. Olufsen, Charles Peskin, Won Yong Kim, Erik M. Pedersen, Ali Nadim, Jesper Larsen

Research output: Contribution to journalArticle

Abstract

Blood flow in the large systemic arteries is modeled using one-dimensional equations derived from the axisymmetric Navier-Stokes equations for flow in compliant and tapering vessels. The arterial tree is truncated after the first few generations of large arteries with the remaining small arteries and arterioles providing outflow boundary conditions for the large arteries. By modeling the small arteries and arterioles as a structured tree, a semi-analytical approach based on a linearized version of the governing equations can be used to derive an expression for the root impedance of the structured tree in the frequency domain. In the time domain, this provides the proper outflow boundary condition. The structured tree is a binary asymmetric tree in which the radii of the daughter vessels are scaled linearly with the radius of the parent vessel. Blood flow and pressure in the large vessels are computed as functions of time and axial distance within each of the arteries. Comparison between the simulations and magnetic resonance measurements in the ascending aorta and nine peripheral locations in one individual shows excellent agreement between the two.

Original languageEnglish (US)
Pages (from-to)1281-1299
Number of pages19
JournalAnnals of Biomedical Engineering
Volume28
Issue number11
DOIs
StatePublished - 2000

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Blood
Boundary conditions
Magnetic resonance measurement
Computer simulation
Navier Stokes equations

ASJC Scopus subject areas

  • Biomedical Engineering

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Numerical simulation and experimental validation of blood flow in arteries with structured-tree outflow conditions. / Olufsen, Mette S.; Peskin, Charles; Kim, Won Yong; Pedersen, Erik M.; Nadim, Ali; Larsen, Jesper.

In: Annals of Biomedical Engineering, Vol. 28, No. 11, 2000, p. 1281-1299.

Research output: Contribution to journalArticle

Olufsen, Mette S. ; Peskin, Charles ; Kim, Won Yong ; Pedersen, Erik M. ; Nadim, Ali ; Larsen, Jesper. / Numerical simulation and experimental validation of blood flow in arteries with structured-tree outflow conditions. In: Annals of Biomedical Engineering. 2000 ; Vol. 28, No. 11. pp. 1281-1299.
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