Nucleic acid nanostructures and topology

Research output: Contribution to journalArticle

Abstract

DNA is well known as the genetic material of all living organisms. However, the properties that allow it to serve so well in that role also can be exploited for chemical ends. Indeed, one of the most promising branches of nanotechnology is predicated on this genetic molecule. It is possible to make stable branched DNA molecules that can be combined through the specificity of cohesion of two ('sticky') ends with complementary overhangs to direct the construction of stick figures. Molecules whose edges consist of double- helical DNA have been constructed which show the connectivities of a cube and of a truncated octahedron. Two-dimensional arrays with programmed structural features have also been built. The topological properties of DNA have been exploited to produce specific knots and Borromean rings. In addition, DNA transitions can be used as the basis of nanomechanical devices. There is far more to DNA than a repository for genetic information!.

Original languageEnglish (US)
Pages (from-to)3221-3238
Number of pages18
JournalAngewandte Chemie - International Edition
Volume37
Issue number23
StatePublished - Dec 17 1998

Fingerprint

Nucleic Acids
Nanostructures
Topology
DNA
Molecules
Nanotechnology

Keywords

  • Catenanes
  • DNA structures
  • Mechanical bonds
  • Nanostructures
  • Topochemistry

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Nucleic acid nanostructures and topology. / Seeman, Nadrian.

In: Angewandte Chemie - International Edition, Vol. 37, No. 23, 17.12.1998, p. 3221-3238.

Research output: Contribution to journalArticle

@article{9b5e77f13a244f8f9ccd36e0fb9a2256,
title = "Nucleic acid nanostructures and topology",
abstract = "DNA is well known as the genetic material of all living organisms. However, the properties that allow it to serve so well in that role also can be exploited for chemical ends. Indeed, one of the most promising branches of nanotechnology is predicated on this genetic molecule. It is possible to make stable branched DNA molecules that can be combined through the specificity of cohesion of two ('sticky') ends with complementary overhangs to direct the construction of stick figures. Molecules whose edges consist of double- helical DNA have been constructed which show the connectivities of a cube and of a truncated octahedron. Two-dimensional arrays with programmed structural features have also been built. The topological properties of DNA have been exploited to produce specific knots and Borromean rings. In addition, DNA transitions can be used as the basis of nanomechanical devices. There is far more to DNA than a repository for genetic information!.",
keywords = "Catenanes, DNA structures, Mechanical bonds, Nanostructures, Topochemistry",
author = "Nadrian Seeman",
year = "1998",
month = "12",
day = "17",
language = "English (US)",
volume = "37",
pages = "3221--3238",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
number = "23",

}

TY - JOUR

T1 - Nucleic acid nanostructures and topology

AU - Seeman, Nadrian

PY - 1998/12/17

Y1 - 1998/12/17

N2 - DNA is well known as the genetic material of all living organisms. However, the properties that allow it to serve so well in that role also can be exploited for chemical ends. Indeed, one of the most promising branches of nanotechnology is predicated on this genetic molecule. It is possible to make stable branched DNA molecules that can be combined through the specificity of cohesion of two ('sticky') ends with complementary overhangs to direct the construction of stick figures. Molecules whose edges consist of double- helical DNA have been constructed which show the connectivities of a cube and of a truncated octahedron. Two-dimensional arrays with programmed structural features have also been built. The topological properties of DNA have been exploited to produce specific knots and Borromean rings. In addition, DNA transitions can be used as the basis of nanomechanical devices. There is far more to DNA than a repository for genetic information!.

AB - DNA is well known as the genetic material of all living organisms. However, the properties that allow it to serve so well in that role also can be exploited for chemical ends. Indeed, one of the most promising branches of nanotechnology is predicated on this genetic molecule. It is possible to make stable branched DNA molecules that can be combined through the specificity of cohesion of two ('sticky') ends with complementary overhangs to direct the construction of stick figures. Molecules whose edges consist of double- helical DNA have been constructed which show the connectivities of a cube and of a truncated octahedron. Two-dimensional arrays with programmed structural features have also been built. The topological properties of DNA have been exploited to produce specific knots and Borromean rings. In addition, DNA transitions can be used as the basis of nanomechanical devices. There is far more to DNA than a repository for genetic information!.

KW - Catenanes

KW - DNA structures

KW - Mechanical bonds

KW - Nanostructures

KW - Topochemistry

UR - http://www.scopus.com/inward/record.url?scp=0032542353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032542353&partnerID=8YFLogxK

M3 - Article

VL - 37

SP - 3221

EP - 3238

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 23

ER -