Novel near-infrared nanoparticulate biomarker: Preparation & stability studies

V. Saxena, M. Sadoqi, S. Kumar, J. Shao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Degradation of Indocyanine green (ICG) in aqueous media, limits its application in early tumor diagnosis and therapy. Thus, the objective of this study is to develop biodegradable nanoparticles entrapping ICG and to establish its effectiveness in providing overall stability to ICG. Nanoparticles entrapping ICG were engineered and characterized. The degradation kinetics of ICG in the nanoparticles was investigated in aqueous media. The degradation of ICG in aqueous nanoparticle suspension followed first-order kinetics. Nanoparticles enhanced aqueous, photo and thermal-stability of ICG.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsA.P. Savitsky, L.Y. Brovko, D.J. Bornhop, R. Raghavachari, S.I. Achilefu
Pages269-275
Number of pages7
Volume5329
DOIs
StatePublished - 2004
EventGenetically Engineered and Optical Probes for Biomedical Applications II - San Jose, CA, United States
Duration: Jan 24 2004Jan 27 2004

Other

OtherGenetically Engineered and Optical Probes for Biomedical Applications II
CountryUnited States
CitySan Jose, CA
Period1/24/041/27/04

Keywords

  • Degradation
  • Fluorescence
  • Indocyanine green
  • Nanoparticles
  • PLGA
  • Stability

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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  • Cite this

    Saxena, V., Sadoqi, M., Kumar, S., & Shao, J. (2004). Novel near-infrared nanoparticulate biomarker: Preparation & stability studies. In A. P. Savitsky, L. Y. Brovko, D. J. Bornhop, R. Raghavachari, & S. I. Achilefu (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5329, pp. 269-275) https://doi.org/10.1117/12.534317