Novel Molecular Scaffolds: Formation of Helical Secondary Structure in a Family of Oligoanthranilamides

Yoshitomo Hamuro, Steven J. Geib, Andrew D. Hamilton

Research output: Contribution to journalArticle


In a simple reaction sequence 2‐nitrobenzoyl chloride, methyl anthranilate, and 2,6‐bis‐(chloroformyl)pyridine are employed to give oligoanthranilamide 1. This compound has a helical structure in solution and in the solid state, and the pitch of the helix can be altered by synthesis of the corresponding pyridine N‐oxide derivative. These types of mimics of the peptide framework are of interest for the de novo design of proteins and drugs. (Figure Presented.)

Original languageEnglish (US)
Pages (from-to)446-448
Number of pages3
JournalAngewandte Chemie International Edition in English
Issue number4
StatePublished - Mar 3 1994


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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