Notch signaling coordinates the patterning of striatal compartments

Heather A. Mason, Staci M. Rakowiecki, Myrto Raftopoulou, Susana Nery, Yuanyuan Huang, Thomas Gridley, Gordon Fishell

Research output: Contribution to journalArticle

Abstract

Numerous lines of evidence suggest that Notch signaling plays a pivotal role in controlling the production of neurons from progenitor cells. However, most experiments have relied on gain-of-function approaches because perturbation of Notch signaling results in death prior to the onset of neurogenesis. Here, we examine the requirement for Notch signaling in the development of the striatum through the analysis of different single and compound Notch1 conditional and Notch3 null mutants. We find that normal development of the striatum depends on the presence of appropriate Notch signals in progenitors during a critical window of embryonic development. Early removal of Notch1 prior to neurogenesis alters early-born patch neurons but not late-born matrix neurons in the striatum. We further show that the late-born striatal neurons in these mutants are spared as a result of functional compensation by Notch3. Notably, however, the removal of Notch signaling subsequent to cells leaving the germinal zone has no obvious effect on striatal organization and patterning. These results indicate that Notch signaling is required in neural progenitor cells to control cell fate in the striatum, but is dispensable during subsequent phases of neuronal migration and differentiation.

Original languageEnglish (US)
Pages (from-to)4247-4258
Number of pages12
JournalDevelopment
Volume132
Issue number19
DOIs
StatePublished - Oct 1 2005

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Corpus Striatum
Neurons
Neurogenesis
Stem Cells
Embryonic Development

Keywords

  • Matrix
  • Neural progenitor
  • Notch 1
  • Notch 3
  • Patch
  • Striatum

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Mason, H. A., Rakowiecki, S. M., Raftopoulou, M., Nery, S., Huang, Y., Gridley, T., & Fishell, G. (2005). Notch signaling coordinates the patterning of striatal compartments. Development, 132(19), 4247-4258. https://doi.org/10.1242/dev.02008

Notch signaling coordinates the patterning of striatal compartments. / Mason, Heather A.; Rakowiecki, Staci M.; Raftopoulou, Myrto; Nery, Susana; Huang, Yuanyuan; Gridley, Thomas; Fishell, Gordon.

In: Development, Vol. 132, No. 19, 01.10.2005, p. 4247-4258.

Research output: Contribution to journalArticle

Mason, HA, Rakowiecki, SM, Raftopoulou, M, Nery, S, Huang, Y, Gridley, T & Fishell, G 2005, 'Notch signaling coordinates the patterning of striatal compartments', Development, vol. 132, no. 19, pp. 4247-4258. https://doi.org/10.1242/dev.02008
Mason HA, Rakowiecki SM, Raftopoulou M, Nery S, Huang Y, Gridley T et al. Notch signaling coordinates the patterning of striatal compartments. Development. 2005 Oct 1;132(19):4247-4258. https://doi.org/10.1242/dev.02008
Mason, Heather A. ; Rakowiecki, Staci M. ; Raftopoulou, Myrto ; Nery, Susana ; Huang, Yuanyuan ; Gridley, Thomas ; Fishell, Gordon. / Notch signaling coordinates the patterning of striatal compartments. In: Development. 2005 ; Vol. 132, No. 19. pp. 4247-4258.
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