Notch activity in neural progenitors coordinates cytokinesis and asymmetric differentiation

Filipe Pinto-Teixeira, Claude Desplan

Research output: Contribution to journalArticle

Abstract

Asymmetric division of neural progenitor cells is a crucial event in the generation of neuronal diversity and involves the segregation of distinct proteins into daughter cells, thereby promoting unique differentiation programs. Although it was known that Notch signaling acts postmitotically to orchestrate differentiation of daughter cells from asymmetrically dividing precursor cells, Bhat reported a previously uncharacterized role for Notch that occurs before cell division to promote the asymmetric localization of the protein Numb and the positioning of the cleavage furrow. Numb is an inhibitor of Notch activity; thus, this mechanism forms a regulatory feedback loop to control asymmetric cytokinesis and differentiation.

Original languageEnglish (US)
Pages (from-to)pe26
JournalScience Signaling
Volume7
Issue number348
DOIs
StatePublished - Oct 21 2014

Fingerprint

Cytokinesis
Cell Division
Cell Differentiation
Proteins
Stem Cells
Cells
Feedback

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Notch activity in neural progenitors coordinates cytokinesis and asymmetric differentiation. / Pinto-Teixeira, Filipe; Desplan, Claude.

In: Science Signaling, Vol. 7, No. 348, 21.10.2014, p. pe26.

Research output: Contribution to journalArticle

@article{faaca75100ce42089924a22cd18ca167,
title = "Notch activity in neural progenitors coordinates cytokinesis and asymmetric differentiation",
abstract = "Asymmetric division of neural progenitor cells is a crucial event in the generation of neuronal diversity and involves the segregation of distinct proteins into daughter cells, thereby promoting unique differentiation programs. Although it was known that Notch signaling acts postmitotically to orchestrate differentiation of daughter cells from asymmetrically dividing precursor cells, Bhat reported a previously uncharacterized role for Notch that occurs before cell division to promote the asymmetric localization of the protein Numb and the positioning of the cleavage furrow. Numb is an inhibitor of Notch activity; thus, this mechanism forms a regulatory feedback loop to control asymmetric cytokinesis and differentiation.",
author = "Filipe Pinto-Teixeira and Claude Desplan",
year = "2014",
month = "10",
day = "21",
doi = "10.1126/scisignal.2005980",
language = "English (US)",
volume = "7",
pages = "pe26",
journal = "Science Signaling",
issn = "1937-9145",
publisher = "American Association for the Advancement of Science",
number = "348",

}

TY - JOUR

T1 - Notch activity in neural progenitors coordinates cytokinesis and asymmetric differentiation

AU - Pinto-Teixeira, Filipe

AU - Desplan, Claude

PY - 2014/10/21

Y1 - 2014/10/21

N2 - Asymmetric division of neural progenitor cells is a crucial event in the generation of neuronal diversity and involves the segregation of distinct proteins into daughter cells, thereby promoting unique differentiation programs. Although it was known that Notch signaling acts postmitotically to orchestrate differentiation of daughter cells from asymmetrically dividing precursor cells, Bhat reported a previously uncharacterized role for Notch that occurs before cell division to promote the asymmetric localization of the protein Numb and the positioning of the cleavage furrow. Numb is an inhibitor of Notch activity; thus, this mechanism forms a regulatory feedback loop to control asymmetric cytokinesis and differentiation.

AB - Asymmetric division of neural progenitor cells is a crucial event in the generation of neuronal diversity and involves the segregation of distinct proteins into daughter cells, thereby promoting unique differentiation programs. Although it was known that Notch signaling acts postmitotically to orchestrate differentiation of daughter cells from asymmetrically dividing precursor cells, Bhat reported a previously uncharacterized role for Notch that occurs before cell division to promote the asymmetric localization of the protein Numb and the positioning of the cleavage furrow. Numb is an inhibitor of Notch activity; thus, this mechanism forms a regulatory feedback loop to control asymmetric cytokinesis and differentiation.

UR - http://www.scopus.com/inward/record.url?scp=84908398537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908398537&partnerID=8YFLogxK

U2 - 10.1126/scisignal.2005980

DO - 10.1126/scisignal.2005980

M3 - Article

VL - 7

SP - pe26

JO - Science Signaling

JF - Science Signaling

SN - 1937-9145

IS - 348

ER -