Noradrenergic regulation of central amygdala in aversive pavlovian-to-instrumental transfer

Vincent D. Campese, Jose M. Soroeta, Elena M. Vazey, Gary Aston-Jones, Joseph Ledoux, Robert M. Sears

Research output: Contribution to journalArticle

Abstract

The neural mechanisms through which a Pavlovian conditioned stimulus (CS) elicits innate defense responses are well understood. But a Pavlovian CS can also invigorate ongoing instrumental responding, as shown by studies of aversive Pavlovian-to-instrumental transfer (PIT). While the neural circuitry of appetitive PIT has been studied extensively, little is known about the brain mechanisms of aversive PIT. We recently showed the central amygdala (CeA) is essential for aversive PIT. In the current studies, using pharmacology and designer receptors in rodents, we demonstrate that noradrenergic (NE) activity negatively regulates PIT via brainstem locus coeruleus (LC) activity and LC projections to CeA. Our results provide evidence for a novel pathway through which response modulation occurs between brainstem neuromodulatory systems and CeA to invigorate adaptive behavior in the face of threat.

Original languageEnglish (US)
Article numbere0224-17.2017
JournaleNeuro
Volume4
Issue number5
DOIs
StatePublished - Sep 1 2017

Fingerprint

Locus Coeruleus
Brain Stem
Psychological Adaptation
Rodentia
Pharmacology
Brain
Central Amygdaloid Nucleus

Keywords

  • Central amygdala
  • Expression
  • Locus coeruleus
  • Motivation
  • Norepinephrine
  • PIT

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Campese, V. D., Soroeta, J. M., Vazey, E. M., Aston-Jones, G., Ledoux, J., & Sears, R. M. (2017). Noradrenergic regulation of central amygdala in aversive pavlovian-to-instrumental transfer. eNeuro, 4(5), [e0224-17.2017]. https://doi.org/10.1523/ENEURO.0224-17.2017

Noradrenergic regulation of central amygdala in aversive pavlovian-to-instrumental transfer. / Campese, Vincent D.; Soroeta, Jose M.; Vazey, Elena M.; Aston-Jones, Gary; Ledoux, Joseph; Sears, Robert M.

In: eNeuro, Vol. 4, No. 5, e0224-17.2017, 01.09.2017.

Research output: Contribution to journalArticle

Campese, VD, Soroeta, JM, Vazey, EM, Aston-Jones, G, Ledoux, J & Sears, RM 2017, 'Noradrenergic regulation of central amygdala in aversive pavlovian-to-instrumental transfer', eNeuro, vol. 4, no. 5, e0224-17.2017. https://doi.org/10.1523/ENEURO.0224-17.2017
Campese, Vincent D. ; Soroeta, Jose M. ; Vazey, Elena M. ; Aston-Jones, Gary ; Ledoux, Joseph ; Sears, Robert M. / Noradrenergic regulation of central amygdala in aversive pavlovian-to-instrumental transfer. In: eNeuro. 2017 ; Vol. 4, No. 5.
@article{c34a76eafb244fd8855441ebd0d558f3,
title = "Noradrenergic regulation of central amygdala in aversive pavlovian-to-instrumental transfer",
abstract = "The neural mechanisms through which a Pavlovian conditioned stimulus (CS) elicits innate defense responses are well understood. But a Pavlovian CS can also invigorate ongoing instrumental responding, as shown by studies of aversive Pavlovian-to-instrumental transfer (PIT). While the neural circuitry of appetitive PIT has been studied extensively, little is known about the brain mechanisms of aversive PIT. We recently showed the central amygdala (CeA) is essential for aversive PIT. In the current studies, using pharmacology and designer receptors in rodents, we demonstrate that noradrenergic (NE) activity negatively regulates PIT via brainstem locus coeruleus (LC) activity and LC projections to CeA. Our results provide evidence for a novel pathway through which response modulation occurs between brainstem neuromodulatory systems and CeA to invigorate adaptive behavior in the face of threat.",
keywords = "Central amygdala, Expression, Locus coeruleus, Motivation, Norepinephrine, PIT",
author = "Campese, {Vincent D.} and Soroeta, {Jose M.} and Vazey, {Elena M.} and Gary Aston-Jones and Joseph Ledoux and Sears, {Robert M.}",
year = "2017",
month = "9",
day = "1",
doi = "10.1523/ENEURO.0224-17.2017",
language = "English (US)",
volume = "4",
journal = "eNeuro",
issn = "2373-2822",
publisher = "Society for Neuroscience",
number = "5",

}

TY - JOUR

T1 - Noradrenergic regulation of central amygdala in aversive pavlovian-to-instrumental transfer

AU - Campese, Vincent D.

AU - Soroeta, Jose M.

AU - Vazey, Elena M.

AU - Aston-Jones, Gary

AU - Ledoux, Joseph

AU - Sears, Robert M.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - The neural mechanisms through which a Pavlovian conditioned stimulus (CS) elicits innate defense responses are well understood. But a Pavlovian CS can also invigorate ongoing instrumental responding, as shown by studies of aversive Pavlovian-to-instrumental transfer (PIT). While the neural circuitry of appetitive PIT has been studied extensively, little is known about the brain mechanisms of aversive PIT. We recently showed the central amygdala (CeA) is essential for aversive PIT. In the current studies, using pharmacology and designer receptors in rodents, we demonstrate that noradrenergic (NE) activity negatively regulates PIT via brainstem locus coeruleus (LC) activity and LC projections to CeA. Our results provide evidence for a novel pathway through which response modulation occurs between brainstem neuromodulatory systems and CeA to invigorate adaptive behavior in the face of threat.

AB - The neural mechanisms through which a Pavlovian conditioned stimulus (CS) elicits innate defense responses are well understood. But a Pavlovian CS can also invigorate ongoing instrumental responding, as shown by studies of aversive Pavlovian-to-instrumental transfer (PIT). While the neural circuitry of appetitive PIT has been studied extensively, little is known about the brain mechanisms of aversive PIT. We recently showed the central amygdala (CeA) is essential for aversive PIT. In the current studies, using pharmacology and designer receptors in rodents, we demonstrate that noradrenergic (NE) activity negatively regulates PIT via brainstem locus coeruleus (LC) activity and LC projections to CeA. Our results provide evidence for a novel pathway through which response modulation occurs between brainstem neuromodulatory systems and CeA to invigorate adaptive behavior in the face of threat.

KW - Central amygdala

KW - Expression

KW - Locus coeruleus

KW - Motivation

KW - Norepinephrine

KW - PIT

UR - http://www.scopus.com/inward/record.url?scp=85032567464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032567464&partnerID=8YFLogxK

U2 - 10.1523/ENEURO.0224-17.2017

DO - 10.1523/ENEURO.0224-17.2017

M3 - Article

C2 - 29071299

AN - SCOPUS:85032567464

VL - 4

JO - eNeuro

JF - eNeuro

SN - 2373-2822

IS - 5

M1 - e0224-17.2017

ER -