Nonrandom development of immunologic abnormalities after infection with human immunodeficiency virus

Implications for immunologic classification of the disease

S. Zolla-Pazner, Don Des Jarlais, S. R. Friedman, T. J. Spira, M. Marmor, R. Holzman, D. Mildvan, S. Yancovitz, U. Mathur-Wagh, J. Garber

Research output: Contribution to journalArticle

Abstract

Blood specimens from 165 intravenous drug users who were seropositive for the human immunodeficiency virus (HIV), from 158 seropositive homosexual men with lymphadenopathy, and from 77 patients with acquired immunodeficiency syndrome (AIDS) were assessed immunologically. Immunologic parameters were analyzed by the Guttman scalogram technique to determine if immunologic abnormalities occurred in a nonrandom pattern. The following four patterns emerged: (i) seropositivity for HIV with no immunologic abnormalities; (ii) seropositivity for HIV with a depressed T4/T8 cell ratio; (iii) seropositivity with a depressed T4/T8 cell ratio and T4-cell depletion; and (iv) seropositivity with a depressed T4/T8 cell ratio, T4-cell depletion, and lymphopenia. Ninety-two to 100% of subjects in each of the three groups of patients were found 'to scale' because the abnormalities occurred in the cumulative, ordered fashion described. This nonrandom occurrence of abnormalities indicates an ordered progression of immunologic abnormalities in individuals infected with HIV, a finding useful in the staging of both symptomatic and asymptomatic HIV-seropositive subjects.

Original languageEnglish (US)
Pages (from-to)5404-5408
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume84
Issue number15
DOIs
StatePublished - Jan 1 1987

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CD4-Positive T-Lymphocytes
Immune System Diseases
CD8-Positive T-Lymphocytes
CD4-CD8 Ratio
HIV
Infection
Lymphopenia
Drug Users
Acquired Immunodeficiency Syndrome

ASJC Scopus subject areas

  • General

Cite this

Nonrandom development of immunologic abnormalities after infection with human immunodeficiency virus : Implications for immunologic classification of the disease. / Zolla-Pazner, S.; Des Jarlais, Don; Friedman, S. R.; Spira, T. J.; Marmor, M.; Holzman, R.; Mildvan, D.; Yancovitz, S.; Mathur-Wagh, U.; Garber, J.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 15, 01.01.1987, p. 5404-5408.

Research output: Contribution to journalArticle

Zolla-Pazner, S. ; Des Jarlais, Don ; Friedman, S. R. ; Spira, T. J. ; Marmor, M. ; Holzman, R. ; Mildvan, D. ; Yancovitz, S. ; Mathur-Wagh, U. ; Garber, J. / Nonrandom development of immunologic abnormalities after infection with human immunodeficiency virus : Implications for immunologic classification of the disease. In: Proceedings of the National Academy of Sciences of the United States of America. 1987 ; Vol. 84, No. 15. pp. 5404-5408.
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