Nonpeptidic foldamers from amino acids

Synthesis and characterization of 1,3-substituted triazole oligomers

Nicholas G. Angelo, Paramjit Arora

Research output: Contribution to journalArticle

Abstract

Nonpeptidic foldamers capable of displaying protein-like functionality were prepared by swapping amide bonds with 1,2,3-triazole rings. The overall conformation of these triazole oligomers is largely dictated by dipole-dipole interactions between adjacent rings. Solution NMR studies suggest that a zigzag conformation, which closely mimics the β-strand structure, predominates in two different tetramers.

Original languageEnglish (US)
Pages (from-to)17134-17135
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number49
DOIs
StatePublished - Dec 14 2005

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Triazoles
Oligomers
Conformations
Amino acids
Amino Acids
Amides
Nuclear magnetic resonance
Proteins

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Nonpeptidic foldamers from amino acids : Synthesis and characterization of 1,3-substituted triazole oligomers. / Angelo, Nicholas G.; Arora, Paramjit.

In: Journal of the American Chemical Society, Vol. 127, No. 49, 14.12.2005, p. 17134-17135.

Research output: Contribution to journalArticle

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