No association between Oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences

Coren L. Apicella, David Cesarini, Magnus Johannesson, Christopher Dawes, Paul Lichtenstein, Björn Wallace, Jonathan Beauchamp, Lars Westberg

    Research output: Contribution to journalArticle

    Abstract

    Background: Oxytocin (OXT) has been implicated in a suite of complex social behaviors including observed choices in economic laboratory experiments. However, actual studies of associations between oxytocin receptor (OXTR) gene variants and experimentally elicited social preferences are rare. Methodology/Principal Findings: We test hypotheses of associations between social preferences, as measured by behavior in two economic games, and 9 single nucleotide polymorphisms (SNPs) of the OXTR gene in a sample of Swedish twins (n=684). Two standard economic games, the dictator game and the trust game, both involving real monetary consequences, were used to elicit such preferences. After correction for multiple hypothesis testing, we found no significant associations between any of the 9 single nucleotide polymorphisms (SNPs) and behavior in either of the games. Conclusion: We were unable to replicate the most significant association reported in previous research between the amount donated in a dictator game and an OXTR genetic variant.

    Original languageEnglish (US)
    Article numbere11153
    JournalPLoS One
    Volume5
    Issue number6
    DOIs
    StatePublished - 2010

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    Oxytocin Receptors
    Polymorphism
    Genes
    Economics
    genetic polymorphism
    economics
    single nucleotide polymorphism
    Single Nucleotide Polymorphism
    Nucleotides
    genes
    Social Behavior
    oxytocin
    Oxytocin
    social behavior
    testing
    Testing
    Research
    oxytocin receptors
    Experiments
    sampling

    ASJC Scopus subject areas

    • Medicine(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)

    Cite this

    Apicella, C. L., Cesarini, D., Johannesson, M., Dawes, C., Lichtenstein, P., Wallace, B., ... Westberg, L. (2010). No association between Oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences. PLoS One, 5(6), [e11153]. https://doi.org/10.1371/journal.pone.0011153

    No association between Oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences. / Apicella, Coren L.; Cesarini, David; Johannesson, Magnus; Dawes, Christopher; Lichtenstein, Paul; Wallace, Björn; Beauchamp, Jonathan; Westberg, Lars.

    In: PLoS One, Vol. 5, No. 6, e11153, 2010.

    Research output: Contribution to journalArticle

    Apicella, CL, Cesarini, D, Johannesson, M, Dawes, C, Lichtenstein, P, Wallace, B, Beauchamp, J & Westberg, L 2010, 'No association between Oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences', PLoS One, vol. 5, no. 6, e11153. https://doi.org/10.1371/journal.pone.0011153
    Apicella, Coren L. ; Cesarini, David ; Johannesson, Magnus ; Dawes, Christopher ; Lichtenstein, Paul ; Wallace, Björn ; Beauchamp, Jonathan ; Westberg, Lars. / No association between Oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences. In: PLoS One. 2010 ; Vol. 5, No. 6.
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