NMR solution structures of adducts derived from the binding of polycyclic aromatic diol epoxides to DNA

M. Cosman, B. E. Hingerty, S. Amin, S. Broyde, N. E. Geacintov, D. J. Patel

Research output: Contribution to journalArticle

Abstract

Site-specifically modified oligonucleotides were derived from the reactions of stereoisomeric polycyclic aromatic diol epoxide metabolite model compounds with oligonucleotides of defined base composition and sequence. The NMR solution structures of ten different adducts studied so far are briefly described, and it is shown that stereochemical factors and the nature of the oligonucleotide context of the complementary strands, exert a powerful influence on the conformational features of these adducts.

Original languageEnglish (US)
Pages (from-to)153-160
Number of pages8
JournalPolycyclic Aromatic Compounds
Volume10
Issue number1-4
StatePublished - 1996

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Oligonucleotides
Epoxy Compounds
DNA
Nuclear magnetic resonance
Metabolites
Chemical analysis

ASJC Scopus subject areas

  • Organic Chemistry

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NMR solution structures of adducts derived from the binding of polycyclic aromatic diol epoxides to DNA. / Cosman, M.; Hingerty, B. E.; Amin, S.; Broyde, S.; Geacintov, N. E.; Patel, D. J.

In: Polycyclic Aromatic Compounds, Vol. 10, No. 1-4, 1996, p. 153-160.

Research output: Contribution to journalArticle

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