Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification

Cristina Teixeira, Hanga Agoston, Frank Beier

Research output: Contribution to journalArticle

Abstract

Coordinated proliferation and differentiation of growth plate chondrocytes is required for endochondral bone growth, but the mechanisms and pathways that control these processes are not completely understood. Recent data demonstrate important roles for nitric oxide (NO) and C-type natriuretic peptide (CNP) in the regulation of cartilage development. Both NO and CNP stimulate the synthesis of cGMP and thus the activation of common downstream pathways. One of these downstream mediators, cGMP-dependent kinase II (cGKII), has itself been shown to be essential for normal endochondral bone formation. This review summarizes our knowledge of the roles and mechanisms of NO, CNP and cGKII signaling in cartilage and endochondral bone development.

Original languageEnglish (US)
Pages (from-to)171-178
Number of pages8
JournalDevelopmental Biology
Volume319
Issue number2
DOIs
StatePublished - Jul 15 2008

Fingerprint

C-Type Natriuretic Peptide
Osteogenesis
Nitric Oxide
Bone Development
Cartilage
Phosphotransferases
Growth Plate
Chondrocytes

Keywords

  • C-type natriuretic peptide
  • Cartilage
  • cGMP
  • cGMP-dependent kinase
  • Endochondral bone
  • MAPK pathways
  • Nitric oxide

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification. / Teixeira, Cristina; Agoston, Hanga; Beier, Frank.

In: Developmental Biology, Vol. 319, No. 2, 15.07.2008, p. 171-178.

Research output: Contribution to journalArticle

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