New paradigms on the transport functions of maturation-stage ameloblasts

Rodrigo Lacruz, C. E. Smith, I. Kurtz, M. J. Hubbard, M. L. Paine

Research output: Contribution to journalArticle

Abstract

Fully matured dental enamel is an architecturally and mechanically complex hydroxyapatite-based bioceramic devoid of most of the organic material that was essential in its making. Enamel formation is a staged process principally involving secretory and maturation stages, each associated with major changes in gene expression and cellular function. Cellular activities that define the maturation stage of amelogenesis include ion (e.g., calcium and phosphate) transport and storage, control of intracellular and extracellular pH (e.g., bicarbonate and hydrogen ion movements), and endocytosis. Recent studies on rodent amelogenesis have identified a multitude of gene products that appear to be linked to these cellular activities. This review describes the main cellular activities of these genes during the maturation stage of amelogenesis.

Original languageEnglish (US)
Pages (from-to)122-129
Number of pages8
JournalJournal of Dental Research
Volume92
Issue number2
DOIs
StatePublished - Feb 2013

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Amelogenesis
Ameloblasts
Dental Enamel
Durapatite
Bicarbonates
Endocytosis
Genes
Protons
Rodentia
Ions
Gene Expression

Keywords

  • amelogenesis
  • biomineralization
  • enamel
  • endocytosis
  • ion transport
  • pH homeostasis

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

New paradigms on the transport functions of maturation-stage ameloblasts. / Lacruz, Rodrigo; Smith, C. E.; Kurtz, I.; Hubbard, M. J.; Paine, M. L.

In: Journal of Dental Research, Vol. 92, No. 2, 02.2013, p. 122-129.

Research output: Contribution to journalArticle

Lacruz, Rodrigo ; Smith, C. E. ; Kurtz, I. ; Hubbard, M. J. ; Paine, M. L. / New paradigms on the transport functions of maturation-stage ameloblasts. In: Journal of Dental Research. 2013 ; Vol. 92, No. 2. pp. 122-129.
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