New approaches to genomic analysis using single molecules

D. C. Schwartz, T. Anantharaman, C. Aston, B. Mishra, V. Clarke, D. Gebauer, S. Delobette, E. Dimalanta, J. Edington, A. Evenzehav, J. Giacalone, C. Hiort, E. Huff, J. Jing, Z. Lail

Research output: Contribution to conferencePaper

Abstract

Despite the rapid progress in the human genome project effort, there is little doubt that radically new conceptual approaches are needed before routine whole genome-based analyses can be undertaken by both basic research and clinical laboratories. Physical mapping of genomes, using restriction endonucleases, has played a major role in the identification and characterization of various loci. Optical mapping is the first practical non-electrophoretic genomic mapping approach. It is a single molecule methodology for the rapid production of ordered restriction maps from single DNA molecules.

Original languageEnglish (US)
Pages248-250
Number of pages3
StatePublished - Jan 1 1998
EventProceedings of the 1998 2nd Annual International Conference on Computational Molecular Biology - New York, NY, USA
Duration: Mar 22 1998Mar 25 1998

Other

OtherProceedings of the 1998 2nd Annual International Conference on Computational Molecular Biology
CityNew York, NY, USA
Period3/22/983/25/98

ASJC Scopus subject areas

  • Computer Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Schwartz, D. C., Anantharaman, T., Aston, C., Mishra, B., Clarke, V., Gebauer, D., Delobette, S., Dimalanta, E., Edington, J., Evenzehav, A., Giacalone, J., Hiort, C., Huff, E., Jing, J., & Lail, Z. (1998). New approaches to genomic analysis using single molecules. 248-250. Paper presented at Proceedings of the 1998 2nd Annual International Conference on Computational Molecular Biology, New York, NY, USA, .