Neutrophil-mediated endogenous analgesia contributes to sex differences in oral cancer pain

Nicole N. Scheff, Aditi Bhattacharya, Edward Dowse, Richard X. Dang, John C. Dolan, Susanna Wang, Hyesung Kim, Donna G. Albertson, Brian L. Schmidt

Research output: Contribution to journalArticle

Abstract

The incidence of oral cancer in the United States is increasing, especially in young people and women. Patients with oral cancer report severe functional pain. Using a patient cohort accrued through the New York University Oral Cancer Center and immune-competent mouse models, we identify a sex difference in the prevalence and severity of oral cancer pain. A neutrophil-mediated endogenous analgesic mechanism is present in male mice with oral cancer. Local naloxone treatment potentiates cancer mediator-induced orofacial nociceptive behavior in male mice only. Tongues from male mice with oral cancer have significantly more infiltrating neutrophils compared to female mice with oral cancer. Neutrophils isolated from the cancer-induced inflammatory microenvironment express beta-endorphin and met-enkephalin. Furthermore, neutrophil depletion results in nociceptive behavior in male mice. These data suggest a role for sex-specific, immune cell-mediated endogenous analgesia in the treatment of oral cancer pain.

Original languageEnglish (US)
Article number52
JournalFrontiers in Integrative Neuroscience
Volume12
DOIs
StatePublished - Oct 22 2018

Fingerprint

Mouth Neoplasms
Sex Characteristics
Analgesia
Neutrophils
Methionine Enkephalin
beta-Endorphin
Cancer Pain
Naloxone
Tongue
Analgesics
Neoplasms
Pain
Incidence
Therapeutics

Keywords

  • Cancer
  • Endogenous analgesia
  • Neutrophils
  • Opioids
  • Orofacial
  • Pain
  • Sex differences
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Neutrophil-mediated endogenous analgesia contributes to sex differences in oral cancer pain. / Scheff, Nicole N.; Bhattacharya, Aditi; Dowse, Edward; Dang, Richard X.; Dolan, John C.; Wang, Susanna; Kim, Hyesung; Albertson, Donna G.; Schmidt, Brian L.

In: Frontiers in Integrative Neuroscience, Vol. 12, 52, 22.10.2018.

Research output: Contribution to journalArticle

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AU - Dowse, Edward

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AU - Dolan, John C.

AU - Wang, Susanna

AU - Kim, Hyesung

AU - Albertson, Donna G.

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