Neurosyphilis in patients with human immunodeficiency virus infection

Edmund C. Tramont, J. Rodriguez-Baño, G. Izquierdo, M. A. Muniain, Marc Gourevitch, Robert S. Klein, Ellie E. Schoenbaum, Steven M. Gordon, Molly E. Eaton, Sheila A. Lukehart, Harold Horowitz, Gary P. Wormser, Konrad Wicher

Research output: Contribution to journalLetter

Abstract

To the Editor: The reports by Gordon et al. and Horowitz et al. (Dec. 1 issue)1,2 appropriately question the effectiveness of high-dose penicillin as a treatment for syphilis in persons infected with the human immunodeficiency virus (HIV). However, these reports do not prove that such treatment is ineffective. The polymerase-chain-reaction (PCR) tests used do not necessarily indicate the presence of replicating organisms. In addition, an immunologic marker, especially a nonspecific one such as the Venereal Disease Research Laboratory (VDRL) or rapid plasma reagin titer, cannot be relied on to indicate successful treatment in persons who are immunologically dysfunctional. Patients.

Original languageEnglish (US)
Pages (from-to)1169-1171
Number of pages3
JournalNew England Journal of Medicine
Volume332
Issue number17
DOIs
StatePublished - Apr 27 1995

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Neurosyphilis
Virus Diseases
HIV
Reagins
Syphilis
Sexually Transmitted Diseases
Penicillins
Therapeutics
Biomarkers
Polymerase Chain Reaction
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tramont, E. C., Rodriguez-Baño, J., Izquierdo, G., Muniain, M. A., Gourevitch, M., Klein, R. S., ... Wicher, K. (1995). Neurosyphilis in patients with human immunodeficiency virus infection. New England Journal of Medicine, 332(17), 1169-1171. https://doi.org/10.1056/NEJM199504273321712

Neurosyphilis in patients with human immunodeficiency virus infection. / Tramont, Edmund C.; Rodriguez-Baño, J.; Izquierdo, G.; Muniain, M. A.; Gourevitch, Marc; Klein, Robert S.; Schoenbaum, Ellie E.; Gordon, Steven M.; Eaton, Molly E.; Lukehart, Sheila A.; Horowitz, Harold; Wormser, Gary P.; Wicher, Konrad.

In: New England Journal of Medicine, Vol. 332, No. 17, 27.04.1995, p. 1169-1171.

Research output: Contribution to journalLetter

Tramont, EC, Rodriguez-Baño, J, Izquierdo, G, Muniain, MA, Gourevitch, M, Klein, RS, Schoenbaum, EE, Gordon, SM, Eaton, ME, Lukehart, SA, Horowitz, H, Wormser, GP & Wicher, K 1995, 'Neurosyphilis in patients with human immunodeficiency virus infection', New England Journal of Medicine, vol. 332, no. 17, pp. 1169-1171. https://doi.org/10.1056/NEJM199504273321712
Tramont EC, Rodriguez-Baño J, Izquierdo G, Muniain MA, Gourevitch M, Klein RS et al. Neurosyphilis in patients with human immunodeficiency virus infection. New England Journal of Medicine. 1995 Apr 27;332(17):1169-1171. https://doi.org/10.1056/NEJM199504273321712
Tramont, Edmund C. ; Rodriguez-Baño, J. ; Izquierdo, G. ; Muniain, M. A. ; Gourevitch, Marc ; Klein, Robert S. ; Schoenbaum, Ellie E. ; Gordon, Steven M. ; Eaton, Molly E. ; Lukehart, Sheila A. ; Horowitz, Harold ; Wormser, Gary P. ; Wicher, Konrad. / Neurosyphilis in patients with human immunodeficiency virus infection. In: New England Journal of Medicine. 1995 ; Vol. 332, No. 17. pp. 1169-1171.
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