Neuropeptides and leukotriene biosynthesis

The effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin

Vincenzo Di Marzo, John R. Tippins, Sehamuddin Galadari, Howard R. Morris

    Research output: Contribution to journalArticle

    Abstract

    The effect of five neuropeptides was tested on platelet activating factor (PAF)-stimulated peptidoleukotriene biosynthesis in rat lungs. Calcitonin and peptide histidine valine-42 (PHV-42) were found to inhibit leukotriene C4 (LTC4) and D4 (LTD4) biosynthesis to an extent similar to the previously reported effects of calcitonin gene-related peptide (CGRP) and peptide histidine isoleucine (PHI) respectively. Helodermin potently inhibited the biosynthesis of all three peptidoleukotrienes. Neuropeptide Y and galanin, both present in airways, enhanced the levels of LTD4 and had no effect on LTC4 or leukotriene E4 (LTE4) levels. The theoretical implications of these findings are discussed.

    Original languageEnglish (US)
    Pages (from-to)169-172
    Number of pages4
    JournalNeuropeptides
    Volume11
    Issue number4
    DOIs
    StatePublished - Jan 1 1988

    Fingerprint

    Galanin
    Leukotriene C4
    Leukotrienes
    Neuropeptide Y
    Calcitonin
    Neuropeptides
    Peptide PHI
    Leukotriene E4
    Leukotriene D4
    Calcitonin Gene-Related Peptide
    Platelet Activating Factor
    Lung
    heliodermin
    peptide histidine valine 42

    ASJC Scopus subject areas

    • Endocrinology
    • Neurology
    • Endocrine and Autonomic Systems
    • Cellular and Molecular Neuroscience

    Cite this

    Neuropeptides and leukotriene biosynthesis : The effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin. / Di Marzo, Vincenzo; Tippins, John R.; Galadari, Sehamuddin; Morris, Howard R.

    In: Neuropeptides, Vol. 11, No. 4, 01.01.1988, p. 169-172.

    Research output: Contribution to journalArticle

    Di Marzo, Vincenzo ; Tippins, John R. ; Galadari, Sehamuddin ; Morris, Howard R. / Neuropeptides and leukotriene biosynthesis : The effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin. In: Neuropeptides. 1988 ; Vol. 11, No. 4. pp. 169-172.
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