Neuropeptide Y Y1 receptor effects on pulpal nociceptors

Jennifer Gibbs, K. M. Harqreaves

Research output: Contribution to journalArticle

Abstract

Neuropeptide Y (NPY) is an important modulatory neuropeptide that regulates several physiological systems, including the activity of sensory neurons. We evaluated whether activation of the NPY Y1 receptor could modulate the activity of capsaicin-sensitive nociceptors in trigeminal ganglia and dental pulp. We tested this hypothesis by measuring capsaicin-stimulated calcitonin gene-related peptide release (CGRP) as a measure of nociceptor activity. Capsaicin-evoked CGRP release was inhibited by 50% (p < 0.05) in trigeminal ganglia and by 26% (p > 0.05) in dental pulp when tissues were pre-treatcd with [Leu 31,Pro 34]NPY. The Yl receptor was found to co-localize with the capsaicin receptor TRPV1 in trigeminal ganglia. These results demonstrate that activation of the Y1 receptor results in the inhibition of the activity of capsaicin-sensitive nociceptors in the trigeminal ganglia and dental pulp. These findings are relevant to the physiological modulation of dental nociceptors by endogenous NPY and demonstrate an important novel analgesic target for the treatment of dental pain.

Original languageEnglish (US)
Pages (from-to)948-952
Number of pages5
JournalJournal of Dental Research
Volume87
Issue number10
DOIs
StatePublished - Oct 2008

Fingerprint

Nociceptors
Capsaicin
Dental Pulp
Trigeminal Ganglion
Calcitonin Gene-Related Peptide
Neuropeptide Y
Tooth
TRPV Cation Channels
Sensory Receptor Cells
Neuropeptides
Analgesics
Pain
neuropeptide Y-Y1 receptor
Therapeutics

Keywords

  • Capsaicin
  • Inflammation
  • NPY
  • Pain
  • Sympathetic
  • Y1

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Neuropeptide Y Y1 receptor effects on pulpal nociceptors. / Gibbs, Jennifer; Harqreaves, K. M.

In: Journal of Dental Research, Vol. 87, No. 10, 10.2008, p. 948-952.

Research output: Contribution to journalArticle

Gibbs, Jennifer ; Harqreaves, K. M. / Neuropeptide Y Y1 receptor effects on pulpal nociceptors. In: Journal of Dental Research. 2008 ; Vol. 87, No. 10. pp. 948-952.
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