Abstract
Recent work suggests that radial glial cells represent many, if not most, of the neuronal progenitors in the developing cortex. Asymmetric cell division of radial glia results in the self-renewal of the radial glial cell and the birth of a neuron. Among the proteins that direct cell fate in Drosophila melanogaster that have known mammalian homologs, Numb is the best candidate to have a similar function in radial glia. During asymmetric divisions of radial glial cells, the basal cell may inherit the radial glial fibre, while the apical cell sequesters the majority of the Numb protein. We suggest two models that make opposite predictions as to whether the radial glia or nascent neuron inherit the radial glial fiber or the majority of the Numb protein.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 34-41 |
| Number of pages | 8 |
| Journal | Current Opinion in Neurobiology |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2003 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Neurons from radial glia : The consequences of asymmetric inheritance. / Fishell, Gordon; Kriegstein, Arnold R.
In: Current Opinion in Neurobiology, Vol. 13, No. 1, 01.01.2003, p. 34-41.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Neurons from radial glia
T2 - The consequences of asymmetric inheritance
AU - Fishell, Gordon
AU - Kriegstein, Arnold R.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Recent work suggests that radial glial cells represent many, if not most, of the neuronal progenitors in the developing cortex. Asymmetric cell division of radial glia results in the self-renewal of the radial glial cell and the birth of a neuron. Among the proteins that direct cell fate in Drosophila melanogaster that have known mammalian homologs, Numb is the best candidate to have a similar function in radial glia. During asymmetric divisions of radial glial cells, the basal cell may inherit the radial glial fibre, while the apical cell sequesters the majority of the Numb protein. We suggest two models that make opposite predictions as to whether the radial glia or nascent neuron inherit the radial glial fiber or the majority of the Numb protein.
AB - Recent work suggests that radial glial cells represent many, if not most, of the neuronal progenitors in the developing cortex. Asymmetric cell division of radial glia results in the self-renewal of the radial glial cell and the birth of a neuron. Among the proteins that direct cell fate in Drosophila melanogaster that have known mammalian homologs, Numb is the best candidate to have a similar function in radial glia. During asymmetric divisions of radial glial cells, the basal cell may inherit the radial glial fibre, while the apical cell sequesters the majority of the Numb protein. We suggest two models that make opposite predictions as to whether the radial glia or nascent neuron inherit the radial glial fiber or the majority of the Numb protein.
UR - http://www.scopus.com/inward/record.url?scp=0037322318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037322318&partnerID=8YFLogxK
U2 - 10.1016/S0959-4388(03)00013-8
DO - 10.1016/S0959-4388(03)00013-8
M3 - Review article
C2 - 12593980
AN - SCOPUS:0037322318
VL - 13
SP - 34
EP - 41
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 1
ER -