Neuronal specification in space and time

Isabel Holguera, Claude Desplan

Research output: Contribution to journalReview article

Abstract

To understand how neurons assemble to form functional circuits, it is necessary to obtain a detailed knowledge of their diversity and to define the developmental specification programs that give rise to this diversity. Invertebrates and vertebrates appear to share common developmental principles of neuronal specification in which cascades of transcription factors temporally pattern progenitors, while spatial cues modify the outcomes of this temporal patterning. Here, we highlight these conserved mechanisms and describe how they are used in distinct neural structures. We present the questions that remain for a better understanding of neuronal specification. Single-cell RNA profiling approaches will potentially shed light on these questions, allowing not only the characterization of neuronal diversity in adult brains, but also the investigation of the developmental trajectories leading to the generation and maintenance of this diversity.

Original languageEnglish (US)
Pages (from-to)176-180
Number of pages5
JournalScience
Volume362
Issue number6411
DOIs
StatePublished - Oct 12 2018

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Invertebrates
Cues
Vertebrates
Transcription Factors
Maintenance
RNA
Neurons
Brain

ASJC Scopus subject areas

  • General

Cite this

Neuronal specification in space and time. / Holguera, Isabel; Desplan, Claude.

In: Science, Vol. 362, No. 6411, 12.10.2018, p. 176-180.

Research output: Contribution to journalReview article

Holguera, Isabel ; Desplan, Claude. / Neuronal specification in space and time. In: Science. 2018 ; Vol. 362, No. 6411. pp. 176-180.
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