Neuronal birthdate underlies the development of striatal compartments

Derek van der Kooy, Gordon Fishell

Research output: Contribution to journalArticle

Abstract

The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underline pattern formation throughout the developing forebrain.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalBrain Research
Volume401
Issue number1
DOIs
StatePublished - Jan 13 1987

Fingerprint

Corpus Striatum
Prosencephalon
Neurons
Thymidine
Young Adult
Cell Proliferation

Keywords

  • Compartment
  • Development
  • Opiate receptor
  • Striatum
  • [H]Thymidine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Neuronal birthdate underlies the development of striatal compartments. / van der Kooy, Derek; Fishell, Gordon.

In: Brain Research, Vol. 401, No. 1, 13.01.1987, p. 155-161.

Research output: Contribution to journalArticle

@article{93130027af7a4349bbd3bf528a457520,
title = "Neuronal birthdate underlies the development of striatal compartments",
abstract = "The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underline pattern formation throughout the developing forebrain.",
keywords = "Compartment, Development, Opiate receptor, Striatum, [H]Thymidine",
author = "{van der Kooy}, Derek and Gordon Fishell",
year = "1987",
month = "1",
day = "13",
doi = "10.1016/0006-8993(87)91176-0",
language = "English (US)",
volume = "401",
pages = "155--161",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Neuronal birthdate underlies the development of striatal compartments

AU - van der Kooy, Derek

AU - Fishell, Gordon

PY - 1987/1/13

Y1 - 1987/1/13

N2 - The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underline pattern formation throughout the developing forebrain.

AB - The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underline pattern formation throughout the developing forebrain.

KW - Compartment

KW - Development

KW - Opiate receptor

KW - Striatum

KW - [H]Thymidine

UR - http://www.scopus.com/inward/record.url?scp=0023133811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023133811&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(87)91176-0

DO - 10.1016/0006-8993(87)91176-0

M3 - Article

VL - 401

SP - 155

EP - 161

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -