Neuronal birthdate underlies the development of striatal compartments

Derek van der Kooy, Gordon Fishell

    Research output: Contribution to journalArticle

    Abstract

    The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underline pattern formation throughout the developing forebrain.

    Original languageEnglish (US)
    Pages (from-to)155-161
    Number of pages7
    JournalBrain Research
    Volume401
    Issue number1
    DOIs
    StatePublished - Jan 13 1987

    Fingerprint

    Corpus Striatum
    Prosencephalon
    Neurons
    Thymidine
    Young Adult
    Cell Proliferation

    Keywords

    • Compartment
    • Development
    • Opiate receptor
    • Striatum
    • [H]Thymidine

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

    Cite this

    Neuronal birthdate underlies the development of striatal compartments. / van der Kooy, Derek; Fishell, Gordon.

    In: Brain Research, Vol. 401, No. 1, 13.01.1987, p. 155-161.

    Research output: Contribution to journalArticle

    van der Kooy, Derek ; Fishell, Gordon. / Neuronal birthdate underlies the development of striatal compartments. In: Brain Research. 1987 ; Vol. 401, No. 1. pp. 155-161.
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