Neuronal activity is required for the development of specific cortical interneuron subtypes

Natalia V. De Marco García, Theofanis Karayannis, Gordon Fishell

Research output: Contribution to journalArticle

Abstract

Electrical activity has been shown to regulate development in a variety of species and in various structures, including the retina, spinal cord and cortex. Within the mammalian cortex specifically, the development of dendrites and commissural axons in pyramidal cells is activity-dependent. However, little is known about the developmental role of activity in the other major cortical population of neurons, the GABA-producing interneurons. These neurons are morphologically and functionally heterogeneous and efforts over the past decade have focused on determining the mechanisms that contribute to this diversity. It was recently discovered that 30% of all cortical interneurons arise from a relatively novel source within the ventral telencephalon, the caudal ganglionic eminence (CGE). Owing to their late birth date, these interneurons populate the cortex only after the majority of other interneurons and pyramidal cells are already in place and have started to functionally integrate. Here we demonstrate in mice that for CGE-derived reelin (Re)-positive and calretinin (Cr)-positive (but not vasoactive intestinal peptide (VIP)-positive) interneurons, activity is essential before postnatal day 3 for correct migration, and that after postnatal day 3, glutamate-mediated activity controls the development of their axons and dendrites. Furthermore, we show that the engulfment and cell motility 1 gene (Elmo1), a target of the transcription factor distal-less homeobox 1 (Dlx1), is selectively expressed in Re + and Cr + interneurons and is both necessary and sufficient for activity-dependent interneuron migration. Our findings reveal a selective requirement for activity in shaping the cortical integration of specific neuronal subtypes.

Original languageEnglish (US)
Pages (from-to)351-355
Number of pages5
JournalNature
Volume472
Issue number7343
DOIs
StatePublished - Apr 21 2011

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Interneurons
Calbindin 2
Pyramidal Cells
Dendrites
Axons
GABAergic Neurons
Telencephalon
Homeobox Genes
Vasoactive Intestinal Peptide
Cell Movement
Retina
Glutamic Acid
Spinal Cord
Transcription Factors
Parturition
Neurons
Population
Genes

ASJC Scopus subject areas

  • Medicine(all)
  • General

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Neuronal activity is required for the development of specific cortical interneuron subtypes. / De Marco García, Natalia V.; Karayannis, Theofanis; Fishell, Gordon.

In: Nature, Vol. 472, No. 7343, 21.04.2011, p. 351-355.

Research output: Contribution to journalArticle

De Marco García, Natalia V. ; Karayannis, Theofanis ; Fishell, Gordon. / Neuronal activity is required for the development of specific cortical interneuron subtypes. In: Nature. 2011 ; Vol. 472, No. 7343. pp. 351-355.
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