Neuroimmune mechanisms in patients with atopic dermatitis during chronic stress

Sol Britt Lonne-Rahm, H. Rickberg, H. El-Nour, P. Mårin, Efrain Azmitia, K. Nordlind

Research output: Contribution to journalArticle

Abstract

Objective: To identify pathoaetiological neuroimmune mechanisms in patients with atopic dermatitis (AD) and chronic stress, focusing at nerve density, sensory neuropeptides, and the serotonergic system. Methods: Eleven patients with AD with histories of stress worsening were included. Biopsies from involved and non-involved skin were processed for immunohistochemistry. Salivary cortisol test was done as a marker for chronic stress. Results: There were more acanthosis and fewer nerve fibres in epidermis and papillary dermis of involved compared with non-involved skin. Whereas there was no significant change in the number of substance P and calcitonin gene-related peptide-positive nerve fibres between the involved and non-involved skin, there was an increase in the epidermal fraction of 5-hydroxtrytamine 1A (5-HT1A) receptor and serotonin transporter protein (SERT) immunoreactivity in the involved skin. The number of 5-HT2AR, CD3-positive cells, and SERT-positive cells, most of them being CD3 positive, was increased in involved skin. There was an increase in mast cells in the involved skin, and these cells were often located close to the basement membrane. There was a strong tendency to a correlation between 5-HT2AR positive cells in the papillary dermis of involved skin and low cortisol ratios, being an indicator of chronic stress. Conclusion: A changed innervation and modulation of the serotonergic system are indicated in chronic atopic eczema also during chronic stress.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalJournal of the European Academy of Dermatology and Venereology
Volume22
Issue number1
DOIs
StatePublished - Jan 2008

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Neuroimmunomodulation
Atopic Dermatitis
Skin
Serotonin Plasma Membrane Transport Proteins
Dermis
Nerve Fibers
Hydrocortisone
Calcitonin Gene-Related Peptide
Substance P
Neuropeptides
Basement Membrane
Epidermis
Mast Cells
Proteins
Immunohistochemistry
Biopsy

Keywords

  • Atopic dermatitis
  • Innervation
  • Mastcells
  • Neuropeptides
  • Receptors
  • Serotonin
  • Stress

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Neuroimmune mechanisms in patients with atopic dermatitis during chronic stress. / Lonne-Rahm, Sol Britt; Rickberg, H.; El-Nour, H.; Mårin, P.; Azmitia, Efrain; Nordlind, K.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 22, No. 1, 01.2008, p. 11-18.

Research output: Contribution to journalArticle

Lonne-Rahm, Sol Britt ; Rickberg, H. ; El-Nour, H. ; Mårin, P. ; Azmitia, Efrain ; Nordlind, K. / Neuroimmune mechanisms in patients with atopic dermatitis during chronic stress. In: Journal of the European Academy of Dermatology and Venereology. 2008 ; Vol. 22, No. 1. pp. 11-18.
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