Neuro-evo-devo in the single cell sequencing era

Nikos Konstantinides, Sophie Degabriel, Claude Desplan

Research output: Contribution to journalReview article

Abstract

The nervous system represents the most complex tissue in animals. How this complexity evolved has been a challenging question to address. The explosion in single cell sequencing techniques, the development of new algorithms to cluster single cells into cell types, along with powerful tools for drawing developmental trajectories offer a unique opportunity to compare homologous cell types between species. They further permit the identification of key developmental points and transcription factors that can lead to the evolution of new cell types. At the same time, the ease of use and efficiency of CRISPR genome editing technology allow validation of predicted regulators. This promises exciting developments in the next few years in the field of neuronal evolution and development.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalCurrent Opinion in Systems Biology
Volume11
DOIs
StatePublished - Oct 1 2018

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Clustered Regularly Interspaced Short Palindromic Repeats
Transcription factors
Neurology
Sequencing
Explosions
Animals
Transcription Factors
Genes
Trajectories
Tissue
Cell
Transcription Factor
Regulator
Explosion
Nervous System
Genome
Trajectory
Technology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Computer Science Applications
  • Drug Discovery
  • Applied Mathematics
  • Modeling and Simulation

Cite this

Neuro-evo-devo in the single cell sequencing era. / Konstantinides, Nikos; Degabriel, Sophie; Desplan, Claude.

In: Current Opinion in Systems Biology, Vol. 11, 01.10.2018, p. 32-40.

Research output: Contribution to journalReview article

Konstantinides, Nikos ; Degabriel, Sophie ; Desplan, Claude. / Neuro-evo-devo in the single cell sequencing era. In: Current Opinion in Systems Biology. 2018 ; Vol. 11. pp. 32-40.
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