Neural Integrator Models

M. S. Goldman, A. Compte, Xiao-Jing Wang

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Abstract

Integration of information across time is a neural computation of critical importance to a variety of brain functions. Examples include oculomotor neural integrators and head direction cells that integrate velocity signals into positional or directional signals, parametric working memory circuits which convert transient input pulses into self-sustained persistent neural activity patterns, and linear ramping neural activity underlying the accumulation of information during decision making. How is integration over long timescales realized in neural circuits? This article reviews experimental and theoretical work related to this fundamental question, with a focus on the idea that recurrent synaptic or cellular mechanisms can instantiate an integration time much longer than intrinsic biophysical time constants of the system. We first introduce some basic concepts and present two types of codes used by neural integrators - the location code and the rate code. Then we summarize models that implement a variety of candidate mechanisms for neural integration in the brain, and we discuss the problem of fine-tuning of model parameters and possible solutions to this problem. Finally, we outline challenges for future research.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages165-178
Number of pages14
ISBN (Print)9780080450469
DOIs
StatePublished - 2010

Fingerprint

Brain
Short-Term Memory
Decision Making
Head
Direction compound

Keywords

  • Accumulation of evidence
  • Decision making
  • Fine-tuning
  • Head direction cell
  • Line attractor
  • NMDA receptor
  • Oculomotor neural integrator
  • Parametric working memory
  • Ring model

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Goldman, M. S., Compte, A., & Wang, X-J. (2010). Neural Integrator Models. In Encyclopedia of Neuroscience (pp. 165-178). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01434-0

Neural Integrator Models. / Goldman, M. S.; Compte, A.; Wang, Xiao-Jing.

Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 165-178.

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Goldman, MS, Compte, A & Wang, X-J 2010, Neural Integrator Models. in Encyclopedia of Neuroscience. Elsevier Ltd, pp. 165-178. https://doi.org/10.1016/B978-008045046-9.01434-0
Goldman MS, Compte A, Wang X-J. Neural Integrator Models. In Encyclopedia of Neuroscience. Elsevier Ltd. 2010. p. 165-178 https://doi.org/10.1016/B978-008045046-9.01434-0
Goldman, M. S. ; Compte, A. ; Wang, Xiao-Jing. / Neural Integrator Models. Encyclopedia of Neuroscience. Elsevier Ltd, 2010. pp. 165-178
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