Neural Circuit of Tail-Elicited Siphon Withdrawal in Aplysia. I. Differential Lateralization of Sensitization and Dishabituation

Adam S. Bristol, Michael A. Sutton, Thomas Carew

Research output: Contribution to journalArticle

Abstract

The tail-elicited siphon withdrawal reflex (TSW) has been a useful preparation in which to study learning and memory in Aplysia. However, comparatively little is known about the neural circuitry that translates tail sensory input (via the P9 nerves to the pleural ganglion) to final reflex output by siphon motor neurons (MNs) in the abdominal ganglion. To address this question, we examined the functional architecture of the TSW circuit by selectively severing nerves of semi-intact preparations and recording either tail-evoked responses in the siphon MNs or measuring siphon withdrawal responses directly. We found that the neural circuit underlying TSW is functionally lateralized. We next tested whether the expression of learning in the TSW reflects the underlying circuit architecture and shows side-specificity. We tested behavioral and physiological correlates of three forms of learning: sensitization, habituation, and dishabituation. Consistent with the circuit architecture, we found that sensitization and habituation of TSW are expressed in a side-specific manner. Unexpectedly, we found that dishabituation was expressed bilaterally, suggesting that a modulatory pathway bridges the two (ipsilateral) input pathways of the circuit, but this path is only revealed for a specific form of learning, dishabituation. These results suggest that the effects of a descending modulatory signal are differentially "gated" during sensitization and dishabituation.

Original languageEnglish (US)
Pages (from-to)666-677
Number of pages12
JournalJournal of Neurophysiology
Volume91
Issue number2
DOIs
StatePublished - Feb 2004

Fingerprint

Aplysia
Tail
Reflex
Learning
Motor Neurons
Ganglia

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Neural Circuit of Tail-Elicited Siphon Withdrawal in Aplysia. I. Differential Lateralization of Sensitization and Dishabituation. / Bristol, Adam S.; Sutton, Michael A.; Carew, Thomas.

In: Journal of Neurophysiology, Vol. 91, No. 2, 02.2004, p. 666-677.

Research output: Contribution to journalArticle

@article{c1d28c94693543d7b0d5bffdcfb0d20a,
title = "Neural Circuit of Tail-Elicited Siphon Withdrawal in Aplysia. I. Differential Lateralization of Sensitization and Dishabituation",
abstract = "The tail-elicited siphon withdrawal reflex (TSW) has been a useful preparation in which to study learning and memory in Aplysia. However, comparatively little is known about the neural circuitry that translates tail sensory input (via the P9 nerves to the pleural ganglion) to final reflex output by siphon motor neurons (MNs) in the abdominal ganglion. To address this question, we examined the functional architecture of the TSW circuit by selectively severing nerves of semi-intact preparations and recording either tail-evoked responses in the siphon MNs or measuring siphon withdrawal responses directly. We found that the neural circuit underlying TSW is functionally lateralized. We next tested whether the expression of learning in the TSW reflects the underlying circuit architecture and shows side-specificity. We tested behavioral and physiological correlates of three forms of learning: sensitization, habituation, and dishabituation. Consistent with the circuit architecture, we found that sensitization and habituation of TSW are expressed in a side-specific manner. Unexpectedly, we found that dishabituation was expressed bilaterally, suggesting that a modulatory pathway bridges the two (ipsilateral) input pathways of the circuit, but this path is only revealed for a specific form of learning, dishabituation. These results suggest that the effects of a descending modulatory signal are differentially {"}gated{"} during sensitization and dishabituation.",
author = "Bristol, {Adam S.} and Sutton, {Michael A.} and Thomas Carew",
year = "2004",
month = "2",
doi = "10.1152/jn.00666.2003",
language = "English (US)",
volume = "91",
pages = "666--677",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Neural Circuit of Tail-Elicited Siphon Withdrawal in Aplysia. I. Differential Lateralization of Sensitization and Dishabituation

AU - Bristol, Adam S.

AU - Sutton, Michael A.

AU - Carew, Thomas

PY - 2004/2

Y1 - 2004/2

N2 - The tail-elicited siphon withdrawal reflex (TSW) has been a useful preparation in which to study learning and memory in Aplysia. However, comparatively little is known about the neural circuitry that translates tail sensory input (via the P9 nerves to the pleural ganglion) to final reflex output by siphon motor neurons (MNs) in the abdominal ganglion. To address this question, we examined the functional architecture of the TSW circuit by selectively severing nerves of semi-intact preparations and recording either tail-evoked responses in the siphon MNs or measuring siphon withdrawal responses directly. We found that the neural circuit underlying TSW is functionally lateralized. We next tested whether the expression of learning in the TSW reflects the underlying circuit architecture and shows side-specificity. We tested behavioral and physiological correlates of three forms of learning: sensitization, habituation, and dishabituation. Consistent with the circuit architecture, we found that sensitization and habituation of TSW are expressed in a side-specific manner. Unexpectedly, we found that dishabituation was expressed bilaterally, suggesting that a modulatory pathway bridges the two (ipsilateral) input pathways of the circuit, but this path is only revealed for a specific form of learning, dishabituation. These results suggest that the effects of a descending modulatory signal are differentially "gated" during sensitization and dishabituation.

AB - The tail-elicited siphon withdrawal reflex (TSW) has been a useful preparation in which to study learning and memory in Aplysia. However, comparatively little is known about the neural circuitry that translates tail sensory input (via the P9 nerves to the pleural ganglion) to final reflex output by siphon motor neurons (MNs) in the abdominal ganglion. To address this question, we examined the functional architecture of the TSW circuit by selectively severing nerves of semi-intact preparations and recording either tail-evoked responses in the siphon MNs or measuring siphon withdrawal responses directly. We found that the neural circuit underlying TSW is functionally lateralized. We next tested whether the expression of learning in the TSW reflects the underlying circuit architecture and shows side-specificity. We tested behavioral and physiological correlates of three forms of learning: sensitization, habituation, and dishabituation. Consistent with the circuit architecture, we found that sensitization and habituation of TSW are expressed in a side-specific manner. Unexpectedly, we found that dishabituation was expressed bilaterally, suggesting that a modulatory pathway bridges the two (ipsilateral) input pathways of the circuit, but this path is only revealed for a specific form of learning, dishabituation. These results suggest that the effects of a descending modulatory signal are differentially "gated" during sensitization and dishabituation.

UR - http://www.scopus.com/inward/record.url?scp=0842327885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0842327885&partnerID=8YFLogxK

U2 - 10.1152/jn.00666.2003

DO - 10.1152/jn.00666.2003

M3 - Article

VL - 91

SP - 666

EP - 677

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 2

ER -