Nanopatterned Bulk Metallic Glass Biosensors

Emily R. Kinser, Jagannath Padmanabhan, Roy Yu, Sydney L. Corona, Jinyang Li, Sagar Vaddiraju, Allen Legassey, Ayomiposi Loye, Jenna Balestrini, Dawson A. Solly, Jan Schroers, Andre Taylor, Fotios Papadimitrakopoulos, Raimund I. Herzog, Themis R. Kyriakides

Research output: Contribution to journalArticle

Abstract

Nanopatterning as a surface area enhancement method has the potential to increase signal and sensitivity of biosensors. Platinum-based bulk metallic glass (Pt-BMG) is a biocompatible material with electrical properties conducive for biosensor electrode applications, which can be processed in air at comparably low temperatures to produce nonrandom topography at the nanoscale. Work presented here employs nanopatterned Pt-BMG electrodes functionalized with glucose oxidase enzyme to explore the impact of nonrandom and highly reproducible nanoscale surface area enhancement on glucose biosensor performance. Electrochemical measurements including cyclic voltammetry (CV) and amperometric voltammetry (AV) were completed to compare the performance of 200 nm Pt-BMG electrodes vs Flat Pt-BMG control electrodes. Glucose dosing response was studied in a range of 2 mM to 10 mM. Effective current density dynamic range for the 200 nm Pt-BMG was 10-12 times greater than that of the Flat BMG control. Nanopatterned electrode sensitivity was measured to be 3.28 μA/cm2/mM, which was also an order of magnitude greater than the flat electrode. These results suggest that nonrandom nanotopography is a scalable and customizable engineering tool which can be integrated with Pt-BMGs to produce biocompatible biosensors with enhanced signal and sensitivity.

Original languageEnglish (US)
Pages (from-to)1779-1787
Number of pages9
JournalACS Sensors
Volume2
Issue number12
DOIs
StatePublished - Dec 22 2017

Fingerprint

Metallic glass
metallic glasses
bioinstrumentation
Biosensors
Platinum
platinum
Electrodes
glucose
glass electrodes
electrodes
sensitivity
Glucose
augmentation
oxidase
Glucose Oxidase
Glucose oxidase
Biocompatible Materials
dynamic range
Voltammetry
enzymes

Keywords

  • biomaterials
  • bulk metallic glass
  • electrochemical biosensor
  • nanorods
  • nanotopography

ASJC Scopus subject areas

  • Bioengineering
  • Fluid Flow and Transfer Processes
  • Process Chemistry and Technology
  • Instrumentation

Cite this

Kinser, E. R., Padmanabhan, J., Yu, R., Corona, S. L., Li, J., Vaddiraju, S., ... Kyriakides, T. R. (2017). Nanopatterned Bulk Metallic Glass Biosensors. ACS Sensors, 2(12), 1779-1787. https://doi.org/10.1021/acssensors.7b00455

Nanopatterned Bulk Metallic Glass Biosensors. / Kinser, Emily R.; Padmanabhan, Jagannath; Yu, Roy; Corona, Sydney L.; Li, Jinyang; Vaddiraju, Sagar; Legassey, Allen; Loye, Ayomiposi; Balestrini, Jenna; Solly, Dawson A.; Schroers, Jan; Taylor, Andre; Papadimitrakopoulos, Fotios; Herzog, Raimund I.; Kyriakides, Themis R.

In: ACS Sensors, Vol. 2, No. 12, 22.12.2017, p. 1779-1787.

Research output: Contribution to journalArticle

Kinser, ER, Padmanabhan, J, Yu, R, Corona, SL, Li, J, Vaddiraju, S, Legassey, A, Loye, A, Balestrini, J, Solly, DA, Schroers, J, Taylor, A, Papadimitrakopoulos, F, Herzog, RI & Kyriakides, TR 2017, 'Nanopatterned Bulk Metallic Glass Biosensors', ACS Sensors, vol. 2, no. 12, pp. 1779-1787. https://doi.org/10.1021/acssensors.7b00455
Kinser ER, Padmanabhan J, Yu R, Corona SL, Li J, Vaddiraju S et al. Nanopatterned Bulk Metallic Glass Biosensors. ACS Sensors. 2017 Dec 22;2(12):1779-1787. https://doi.org/10.1021/acssensors.7b00455
Kinser, Emily R. ; Padmanabhan, Jagannath ; Yu, Roy ; Corona, Sydney L. ; Li, Jinyang ; Vaddiraju, Sagar ; Legassey, Allen ; Loye, Ayomiposi ; Balestrini, Jenna ; Solly, Dawson A. ; Schroers, Jan ; Taylor, Andre ; Papadimitrakopoulos, Fotios ; Herzog, Raimund I. ; Kyriakides, Themis R. / Nanopatterned Bulk Metallic Glass Biosensors. In: ACS Sensors. 2017 ; Vol. 2, No. 12. pp. 1779-1787.
@article{419f2ba5484e4a49bab8697cefb7d3be,
title = "Nanopatterned Bulk Metallic Glass Biosensors",
abstract = "Nanopatterning as a surface area enhancement method has the potential to increase signal and sensitivity of biosensors. Platinum-based bulk metallic glass (Pt-BMG) is a biocompatible material with electrical properties conducive for biosensor electrode applications, which can be processed in air at comparably low temperatures to produce nonrandom topography at the nanoscale. Work presented here employs nanopatterned Pt-BMG electrodes functionalized with glucose oxidase enzyme to explore the impact of nonrandom and highly reproducible nanoscale surface area enhancement on glucose biosensor performance. Electrochemical measurements including cyclic voltammetry (CV) and amperometric voltammetry (AV) were completed to compare the performance of 200 nm Pt-BMG electrodes vs Flat Pt-BMG control electrodes. Glucose dosing response was studied in a range of 2 mM to 10 mM. Effective current density dynamic range for the 200 nm Pt-BMG was 10-12 times greater than that of the Flat BMG control. Nanopatterned electrode sensitivity was measured to be 3.28 μA/cm2/mM, which was also an order of magnitude greater than the flat electrode. These results suggest that nonrandom nanotopography is a scalable and customizable engineering tool which can be integrated with Pt-BMGs to produce biocompatible biosensors with enhanced signal and sensitivity.",
keywords = "biomaterials, bulk metallic glass, electrochemical biosensor, nanorods, nanotopography",
author = "Kinser, {Emily R.} and Jagannath Padmanabhan and Roy Yu and Corona, {Sydney L.} and Jinyang Li and Sagar Vaddiraju and Allen Legassey and Ayomiposi Loye and Jenna Balestrini and Solly, {Dawson A.} and Jan Schroers and Andre Taylor and Fotios Papadimitrakopoulos and Herzog, {Raimund I.} and Kyriakides, {Themis R.}",
year = "2017",
month = "12",
day = "22",
doi = "10.1021/acssensors.7b00455",
language = "English (US)",
volume = "2",
pages = "1779--1787",
journal = "ACS Sensors",
issn = "2379-3694",
publisher = "American Chemical Society",
number = "12",

}

TY - JOUR

T1 - Nanopatterned Bulk Metallic Glass Biosensors

AU - Kinser, Emily R.

AU - Padmanabhan, Jagannath

AU - Yu, Roy

AU - Corona, Sydney L.

AU - Li, Jinyang

AU - Vaddiraju, Sagar

AU - Legassey, Allen

AU - Loye, Ayomiposi

AU - Balestrini, Jenna

AU - Solly, Dawson A.

AU - Schroers, Jan

AU - Taylor, Andre

AU - Papadimitrakopoulos, Fotios

AU - Herzog, Raimund I.

AU - Kyriakides, Themis R.

PY - 2017/12/22

Y1 - 2017/12/22

N2 - Nanopatterning as a surface area enhancement method has the potential to increase signal and sensitivity of biosensors. Platinum-based bulk metallic glass (Pt-BMG) is a biocompatible material with electrical properties conducive for biosensor electrode applications, which can be processed in air at comparably low temperatures to produce nonrandom topography at the nanoscale. Work presented here employs nanopatterned Pt-BMG electrodes functionalized with glucose oxidase enzyme to explore the impact of nonrandom and highly reproducible nanoscale surface area enhancement on glucose biosensor performance. Electrochemical measurements including cyclic voltammetry (CV) and amperometric voltammetry (AV) were completed to compare the performance of 200 nm Pt-BMG electrodes vs Flat Pt-BMG control electrodes. Glucose dosing response was studied in a range of 2 mM to 10 mM. Effective current density dynamic range for the 200 nm Pt-BMG was 10-12 times greater than that of the Flat BMG control. Nanopatterned electrode sensitivity was measured to be 3.28 μA/cm2/mM, which was also an order of magnitude greater than the flat electrode. These results suggest that nonrandom nanotopography is a scalable and customizable engineering tool which can be integrated with Pt-BMGs to produce biocompatible biosensors with enhanced signal and sensitivity.

AB - Nanopatterning as a surface area enhancement method has the potential to increase signal and sensitivity of biosensors. Platinum-based bulk metallic glass (Pt-BMG) is a biocompatible material with electrical properties conducive for biosensor electrode applications, which can be processed in air at comparably low temperatures to produce nonrandom topography at the nanoscale. Work presented here employs nanopatterned Pt-BMG electrodes functionalized with glucose oxidase enzyme to explore the impact of nonrandom and highly reproducible nanoscale surface area enhancement on glucose biosensor performance. Electrochemical measurements including cyclic voltammetry (CV) and amperometric voltammetry (AV) were completed to compare the performance of 200 nm Pt-BMG electrodes vs Flat Pt-BMG control electrodes. Glucose dosing response was studied in a range of 2 mM to 10 mM. Effective current density dynamic range for the 200 nm Pt-BMG was 10-12 times greater than that of the Flat BMG control. Nanopatterned electrode sensitivity was measured to be 3.28 μA/cm2/mM, which was also an order of magnitude greater than the flat electrode. These results suggest that nonrandom nanotopography is a scalable and customizable engineering tool which can be integrated with Pt-BMGs to produce biocompatible biosensors with enhanced signal and sensitivity.

KW - biomaterials

KW - bulk metallic glass

KW - electrochemical biosensor

KW - nanorods

KW - nanotopography

UR - http://www.scopus.com/inward/record.url?scp=85039153875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039153875&partnerID=8YFLogxK

U2 - 10.1021/acssensors.7b00455

DO - 10.1021/acssensors.7b00455

M3 - Article

VL - 2

SP - 1779

EP - 1787

JO - ACS Sensors

JF - ACS Sensors

SN - 2379-3694

IS - 12

ER -