Multivariate modeling of longitudinal MRI in early brain development with confidence measures

Neda Sadeghi, Marcel Prastawa, P. Thomas Fletcher, Clement Vachet, Bo Wang, John Gilmore, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The human brain undergoes rapid organization and structuring early in life. Longitudinal imaging enables the study of these changes over a developmental period within individuals through estimation of population growth trajectory and its variability. In this paper, we focus on maturation of white and gray matter depicted in structural and diffusion MRI of healthy subjects with repeated scans. We provide a framework for joint analysis of both structural MRI and DTI (Diffusion Tensor Imaging) using multivariate nonlinear mixed effect modeling of temporal changes. Our framework constructs normative growth models for all the modalities, taking into account the correlation among the modalities and individuals, along with estimation of the variability of the population trends. We apply our method to study early brain development, and to our knowledge this is the first multimodel longitudinal modeling of diffusion and signal intensity changes for this growth stage. Results show the potential of our framework to study growth trajectories, as well as neurodevelopmental disorders through comparison against the constructed normative models of multimodal 4D MRI.

    Original languageEnglish (US)
    Title of host publicationISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro
    Pages1400-1403
    Number of pages4
    DOIs
    StatePublished - 2013
    Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
    Duration: Apr 7 2013Apr 11 2013

    Other

    Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
    CountryUnited States
    CitySan Francisco, CA
    Period4/7/134/11/13

    Fingerprint

    Magnetic resonance imaging
    Brain
    Growth Disorders
    Diffusion Magnetic Resonance Imaging
    Diffusion Tensor Imaging
    Growth
    Healthy Volunteers
    Trajectories
    Organizations
    Diffusion tensor imaging
    Population
    Imaging techniques
    Population Forecast
    White Matter
    Gray Matter
    Neurodevelopmental Disorders

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

    Cite this

    Sadeghi, N., Prastawa, M., Fletcher, P. T., Vachet, C., Wang, B., Gilmore, J., & Gerig, G. (2013). Multivariate modeling of longitudinal MRI in early brain development with confidence measures. In ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro (pp. 1400-1403). [6556795] https://doi.org/10.1109/ISBI.2013.6556795

    Multivariate modeling of longitudinal MRI in early brain development with confidence measures. / Sadeghi, Neda; Prastawa, Marcel; Fletcher, P. Thomas; Vachet, Clement; Wang, Bo; Gilmore, John; Gerig, Guido.

    ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro. 2013. p. 1400-1403 6556795.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Sadeghi, N, Prastawa, M, Fletcher, PT, Vachet, C, Wang, B, Gilmore, J & Gerig, G 2013, Multivariate modeling of longitudinal MRI in early brain development with confidence measures. in ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro., 6556795, pp. 1400-1403, 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013, San Francisco, CA, United States, 4/7/13. https://doi.org/10.1109/ISBI.2013.6556795
    Sadeghi N, Prastawa M, Fletcher PT, Vachet C, Wang B, Gilmore J et al. Multivariate modeling of longitudinal MRI in early brain development with confidence measures. In ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro. 2013. p. 1400-1403. 6556795 https://doi.org/10.1109/ISBI.2013.6556795
    Sadeghi, Neda ; Prastawa, Marcel ; Fletcher, P. Thomas ; Vachet, Clement ; Wang, Bo ; Gilmore, John ; Gerig, Guido. / Multivariate modeling of longitudinal MRI in early brain development with confidence measures. ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro. 2013. pp. 1400-1403
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